ACS, Clonal Hematopoiesis of Indeterminate Potential, Smoking Cessation
Conditions
Brief summary
In order to identify the association between clonal hematopoiesis of indeterminate potential (CHIP) and cardiovascular risks after smoking cessation, this study intends to recruit ACS patients undergoing complete revascularization and perform whole-exome sequencing for enrolled patients to identify the prevalence of CHIP mutations. After 1-year follow-up, the relationship of presence of CHIP mutations and the occurrence of MACCEs will be explored, irrespective of smoking cessation or not. CHIP may be a potential risk factor of poor prognosis of ACS.
Interventions
GENETICclonal hematopoiesis of indeterminate potential
Whole-exome sequencing is performed to detect the presence of clonal hematopoiesis of indeterminate potential (CHIP)
Sponsors
Shenyang Northern Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* 1\. In-patients with acute coronary syndrome to undergo PCI 2. Complete revascularization during the index hospitalization 3. Written informed consent
Exclusion criteria
* 1\. Periprocedural complications (coronary artery dissection, perforation, myocardial infarction, stroke, death) 2. Planned coronary revascularization at discharge 3. Patients with severe chronic disease (uremia, liver cirrhosis, COPD (chronic obstructive pulmonary disease) 4. Abnormal blood counts caused by hematological diseases 5. Diagnosed malignancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| prevalence of CHIP mutations | 24 hours | Whole-exome sequencing is performed to detect the presence of CHIP mutations |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| MACCE | 1 year | MACCE includes cardiac death, non-fatal MI, non-fatal stroke, rehospitalization due to heart failure, ischemia-driven revascularization at 12 months |
Countries
China
Outcome results
None listed