Allergic Rhinitis, Asthma, Atopic Dermatitis, Conjunctivitis
Conditions
Keywords
House dust mite, Der p 1, Der p 2, China
Brief summary
One hundred patients were enrolled, based on sensitization and doctor-diagnosed allergy to HDM. Questionnaires were administered to document demographic and clinical characteristics. Serum IgE reactivity toDermatophagoides pteronyssinus (Dp) extract, Der p 1, Der p 2 and Der p 10 was measured by ImmunoCAP.
Detailed description
Background: The role of specific IgE (sIgE) against Der p 1and Der p 2 in Chinese patients with house dust mite (HDM)allergy has not yet been well investigated.Methods: One hundred patients were enrolled, based on sensitization and doctor-diagnosed allergy to HDM. Questionnaires were administered to document demographic and clinical characteristics. Serum IgE reactivity toDermatophagoides pteronyssinus (Dp) extract, Der p 1, Der p 2 and Der p 10 was measured by ImmunoCAP.
Interventions
None listed
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
3 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* HDM-allergic patients reporting allergic rhinitis, conjunctivitis, asthma and/or atopic dermatitis and who had never undergone immunotherapy, were enrolled if they were sensitized to Dp as judged by ImmunoCAP ( ≥ 1 kU/l) and/or skin reaction index (SRI)by skin-prick test (SPT, a wheal diameter ≥ 0.5 mm).
Exclusion criteria
* Patients who refused to participate in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Demographic Characteristics | 1 year | Describe the patient's basic information in detail, including age, gender, family history, etc |
| Der p 1 Serum IgE | 1 year | Prevalence of Der p 1 Serum IgE in HDM-Allergic Patients |
| Der p 2 Serum IgE | 1 year | Prevalence of Der p 2 Serum IgE in HDM-Allergic Patients |
| Dp, Der p 1 and Der p 2 | 1 year | Relationship between Serum IgE Levels of Dp, Der p 1 and Der p 2 |
| Factors associated with specific IgE against Der p 1 | 1 year | Study the patient's basic information and identify factors that are clearly associated with specific IgE against Der p 1 |
| Factors associated with specific IgE against Der p 2 | 1 year | Study the patient's basic information and identify factors that are clearly associated with specific IgE against Der p 2 |
| the Number of Affected Organs | 1 year | Association of Specific IgE Titers with the Number of Affected Organs |
Countries
China
Outcome results
None listed