CaIMR, Prognosis, ST-segment Elevation Myocardial Infarction
Conditions
Brief summary
The coronary artery system is composed of three different types of blood vessels, namely epicardial arteries, arterioles and capillaries. Compared with epicardial arteries, arterioles and capillaries are lower than the resolution of current angiography systems, so angiography cannot be used for visualization. Existing studies have shown that coronary microcirculation plays an extremely important role in maintaining full myocardial perfusion. Coronary microvascular disorders can lead to myocardial hypoperfusion and ischemia, and are related to the poor prognosis of patients with coronary heart disease. At present, there is no technology that can directly detect the state of the coronary microcirculation in the human body, but the coronary microcirculation function can be indirectly assessed through two invasive and non-invasive methods. Among them, the index of microcirculation resistance (IMR) is widely used to evaluate coronary microcirculation function \[3\]. However, in the case of epicardial stenosis, accurate determination of IMR requires knowledge of coronary artery contraction pressure (Pw). However, measuring IMR is an invasive examination technique, and measuring IMR requires high technical requirements for the operator. Therefore, the CaIMR value obtained by AI technology can well overcome this limitation, and the existing data show that the CaIMR value has a good correlation with the IMR value. However, CaIMR has a clinical prognosis for patients with acute ST-segment elevation myocardial infarction. The predictive value of CaIMR has not yet been explored. This project aims to evaluate the application value of CaIMR in predicting the occurrence of adverse cardiovascular events in patients with acute ST-segment elevation myocardial infarction after percutaneous coronary intervention.
Interventions
None listed
Sponsors
Zhongnan Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients who are clinically diagnosed with acute ST-segment elevation myocardial infarction and are planned to undergo PCI; * Volunteer to participate and sign the informed consent
Exclusion criteria
* Coronary angiography suggests that it is not suitable for PCI; * Have performed CABG surgery in the past; * Lesion of left or right coronary ostium; * The target vessel is an infarct-related artery (old or acute myocardial infarction recovery period); * The immediate effect of target vessel PCI is not ideal (such as: final TIMI blood flow \<grade 3, dissection with restricted blood flow, side branch occlusion with diameter\> 1.5 mm, distal embolism or thrombus shown by angiography); * Severe systemic infection; * Patients with malignant wasting disease whose estimated survival time is less than 1 year.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The composite endpoint of all-cause death and heart failure rehospitalization | 1 year after surgery | The composite endpoint of all-cause death and heart failure rehospitalization |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The composite endpoint of all-cause death and heart failure rehospitalization | 1 month after surgery | The composite endpoint of all-cause death and heart failure rehospitalization |
| All-cause death | 1 year after surgery | All-cause death |
| Heart failure rehospitalization | 1 year after surgery | Heart failure rehospitalization |
| Cardiogenic Rehospitalization | 1 year after surgery | Cardiogenic Rehospitalization |
Countries
China
Contacts
Primary ContactZhibing Lu, MD, PhD
Outcome results
None listed