Plasma, Urine and Tear Omics Changes in Different Diets

Plasma, Urine and Tear Omics Changes Based on Protein and Metabonomics Technology in Different Diets and Screening of Healthy Diet Markers

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04984642

Enrollment

Registered

2021-07-30

Start date

2021-07-01

Completion date

2022-12-31

Last updated

2025-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diet, Healthy

Brief summary

The study plans to start in July 2021, and it is expected that 20 healthy people (aged 18-70 years old, BMI 18.5-40kg/m2) will carry out a 5-week intervention and follow-up. Participants will be enrolled in the group through the screening and plan to take regular diet, OGTT, high-fat diet, low-calorie diet and ketogenic diet within 5 weeks. The proteomics and metabolomics indicators of tear, plasma, and urine specimens will be measured at 5 time points at baseline, 30 minutes, 1 hour, 2 hours, and 3 hours for each diet. The correlation of proteomics and metabolomics indicators with classic laboratory parameters (BMI, HDL, LDL, cholesterol, triglyceride levels, and insulin resistance (HOMA-IR)) will be analyzed.

Interventions

OTHERdiet

have OGTT,normal diet, high fat diet, low calorie diet, and ketogenic diet in turn

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

SCREENING

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

1. Healthy individuals aged 20-70 years, with a body mass index (BMI) of 18.5-40 kg/m². 2. No known chronic medical conditions. 3. Willingness to comply with study requirements and adhere to the intervention protocol.

Exclusion criteria

1. Presence of significant medical conditions or chronic diseases. 2. Diagnosis of diabetes mellitus or prediabetes. 3. Triglyceride level ≥4 mmol/L. 4. Blood pressure ≥160/100 mmHg or presence of malignant hypertension. 5. History of an eating disorder. 6. Previous bariatric surgery. 7. Severe gastrointestinal diseases. 8. History of diarrhea within the past two weeks. 9. Special dietary requirements or known food allergies. 10. Pregnancy or breastfeeding.

Design outcomes

Primary

Measure	Time frame	Description
Proteomics and metabolomics changes after diet intervention	5 weeks	Changes of plasma, urine, tear proteomics and metabolomics after diet intervention

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026