Healthy, Heart Failure
Conditions
Brief summary
The purpose of this study is to understand if breathing muscle training combined with cardiac rehabilitation influences the blood flow and blood pressure response during exercise.
Interventions
DEVICEInspiratory muscle training
Inspiratory muscle training for 12 weeks at 40% maximal inspiratory pressure
Sponsors
Mayo Clinic
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
- Heart Failure Group: * Adult 18 years and older. * English speaking. * Has a qualifying heart failure indication for center-based cardiac rehabilitation. Inclusion Criteria - Healthy Control Group: * Adult 18 years and older. * English speaking. * Absence of pulmonary, cardiovascular, musculoskeletal, neurologic, or orthopedic diseases. Controls will be matched for age and sex.
Exclusion criteria
* HF patients who are unable to engage in a regularly structured exercise training program as part of a clinically indicated center-based outpatient cardiac rehabilitation program. * Participants unable/unwilling to provide informed consent. * Uremia, history of allergy to iodides. Impaired renal function. * Creatinine value greater than 1.3 mg/dL (via clinical record within the past 6 months). * Diagnosis of liver disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood pressure response | baseline and 12 week follow up | Mean arterial pressure |
| Change in blood flow response | baseline and 12 week follow up | respiratory muscle blood flow |
| Change in limb vascular resistance response | baseline and 12 week follow up | Limb vascular resistance |
Countries
United States
Contacts
CONTACTEric Bruhn, MA
CONTACTJoshua Smith
PRINCIPAL_INVESTIGATORJoshua Smith, PhD
Mayo Clinic
Outcome results
None listed