Propolis Versus Calcium Hydroxide on Post-Operative Pain in Patients With Necrotic Pulp

Evaluation of the Effect of Propolis Versus Calcium Hydroxide, Intracanal Medicaments on Post-Operative Pain in Patients With Necrotic Pulp (A Randomized Clinical Trial)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04983524

Enrollment

Registered

2021-07-30

Start date

2015-10-31

Completion date

2018-05-31

Last updated

2021-07-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Necrotic Pulp, Post-Operative Pain, Chronic

Keywords

calcium hydroxide, propolis, post-operative pain, necrotic pulp

Brief summary

Propolis is a resinous product of honeybees. Propolis is said to be effective against resistant microorganisms inside the root canal compared to the gold standard medication known as calcium hydroxide. The clinical trial tests the effect of propolis versus calcium hydroxide on pain in patients with necrotic teeth.

Detailed description

Propolis is an immunomodulatory, antioxidant, flavonoid-rich resinous product of honeybees. Propolis was reported as less cytotoxic and more effective against resistant microorganisms than calcium hydroxide as well as biocompatible to the periradicular tissues than existing intracanal medicaments. The aim of this single-blinded randomized clinical trial was to evaluate the effect of propolis versus calcium hydroxide, intracanal medicaments, on post-operative pain in patients with necrotic single canal teeth. Methods: Forty-six participants with an age range of 20-40 years old, diagnosed as having necrotic pulp in their single-rooted, single canal teeth were included in this study, with 23 participants in each group. Treatment was done in two visits and intracanal medicament was applied for one week in between. Participants were instructed to rate their pain score by a numerical rating scale after 24, 48, 72 hours and at 7 days.

Interventions

DIETARY_SUPPLEMENTpropolis

resinous product of honeybees

DRUGCalcium Hydroxide

Gold standard control intracanal medicament

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

20 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* • Asymptomatic patients with age range 20 - 40 years * Necrotic, single canal maxillary and mandibular teeth with periapical infection presented as radiolucency or widening in the periodontal membrane space. * Medically - free of any systemic disease * Teeth with complete root formation

Exclusion criteria

* • Pregnant or lactating females * Teeth with vital pulps, internal or external resorption or anatomic abnormalities * Teeth with cracks, curvatures, root caries and calcified canals * Double or triple-rooted teeth * Patients with facial swelling, acute pulpal or periapical lesion * Teeth that are not indicated for endodontic treatment: Bad oral hygiene, mobile or recessed * Previously endodontically-treated teeth

Design outcomes

Primary

Measure	Time frame	Description
post-operative pain	one week. line of 10 points	Categorical data on numerical rating scale

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026