Effects of Different Polyphenol-containing Beverages on the Immune System and on Muscular Growth Factors

Effects of Different Polyphenol-containing Beverages on the Immune System and on Muscular Growth Factors - a Pilot Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04983420

Enrollment

Registered

2021-07-30

Start date

2021-01-01

Completion date

2023-05-31

Last updated

2023-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Food Sensitivity

Brief summary

In this research project, the effect of different polyphenol-containing beverages with varying alcohol content of \< 0.4 vol% on immune function as well as muscular growth factors will be investigated

Interventions

OTHERnon-alcoholic Pilsner

intake of 1 L non-alcoholic Pilsner per day for 2 weeks

OTHERnon-alcoholic wheat beer

intake of 1 L non-alcoholic wheat beer per day for 2 weeks

OTHERapple spritzer

intake of 1 L apple spritzer per day for 2 weeks

OTHERlemonade

intake of 1 L lemonade per day for 2 weeks

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

OTHER

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy * Age 20 - 60 years * Written informed consent

Exclusion criteria

* severe gastrointestinal disease or known malabsorption * use of proton pump inhibitors * malignancies * rheumatoid diseases * metabolic syndrome * acute or chronic infections or inflammatory diseases * use of medications or supplements to interfere with immune function * alcohol and/or drug abuse or addiction * dependent relationship with the project manager or his or her employees * pregnancy or breastfeeding * chronic illness or regular use of medication (except hormonal contraception) * smoker

Design outcomes

Primary

Measure	Time frame	Description
white blood cells	before beverage intake	white blood cell count
inflammatory markers in the blood	before beverage intake	IL-6, TNF- α, hs-CRP
blood alcohol	before beverage intake	blood alcohol level
polyphenol in the urine	before beverage intake	polyphenol level in the urine

Secondary

Measure	Time frame	Description
dietary habit	before beverage intake and day 12-14 of beverage intake	3 day food diary
physical activity	before beverage intake	Global Physical Activity Questionnaire (allows to calculate metabolic equivalents to express the intensity of physical activities

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026