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Portsmouth CORE-D Routine Care Data Repository

Portsmouth Clinical Outcomes REsearch Database (CORE-D)- a Research Database of Routine Electronically Recorded Patient Data to Model Adverse Clinical Outcomes and Healthcare Resource Usage

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04983082
Acronym
CORE-D
Enrollment
750000
Registered
2021-07-30
Start date
2021-08-19
Completion date
2031-04-01
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult Hospital Patients at Risk of Adverse Outcomes

Brief summary

An integrated database of depersonalised routine hospital patient data consisting of demographic and disease attributes, physiological or laboratory measurements, care contacts and interventions along with associated clinical outcomes. The database is an essential resource for the development and testing of risk models and classification systems, modified as necessary for patient subgroups, which can then be introduced into clinical care to improve patient outcomes. It can also be used for large scale simulations to evaluate interventions.

Detailed description

The aims and objectives of this database of depersonalised routinely collected hospital patient data are to: * Conduct epidemiological and observational studies of acute hospital care. * Develop and use algorithms and risk models to identify the deteriorating / sick adult so that interventions and enhanced care can be provided in a timelier manner with consequent resource and outcome improvements. This covers both the deteriorating inpatient at risk of adverse outcomes and people in the local community at risk of hospitalisation or in need of other health services. * Retrospectively evaluate interventions e.g. impact of system-wide clinical pathway introduction * Conduct simulations of clinical pathways

Interventions

None listed

Sponsors

Portsmouth Hospitals NHS Trust
Lead SponsorOTHER_GOV

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
16 Years to No maximum

Inclusion criteria

* Adult presenting at the acute hospital or receiving services from the hospital

Exclusion criteria

* Adults who have registered an opt out of research with National Health Service (NHS) Digital * Adults who have contacted the hospital to ask that their records are not to be included in this study

Design outcomes

Primary

MeasureTime frameDescription
In-hospital deathAt 24 hours after an observation assessment or physiological measurementDeath during hospital admission
Unanticipated ICU admissionAt 24 hours after an observation assessment or physiological measurementUnanticipated ICU admission during hospital stay
Cardiac arrestAt 24 hours after an observation assessment or physiological measurementCardiac arrest during hospital stay

Secondary

MeasureTime frameDescription
Diagnosis of Corona Virus Disease (COVID) infection48 hours after presentationDiagnosis of COVID-19
Detection of Acute Organ Dysfunction24 hours after presentationDetection of acute organ dysfunction as measured by components of the Sequential Organ Failure Assessment (SOFA) Score

Countries

United Kingdom

Contacts

CONTACTPaul Meredith, PhD
paul.meredith@porthosp.nhs.uk023 92286000
CONTACTAlice Mortlock, PhD
alice.mortlock@porthosp.nhs.uk023 92286000
PRINCIPAL_INVESTIGATORPaul E Schmidt, MRCP

Portsmouth Hospitals NHS Trust

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 30, 2026