Post-Concussion Syndrome
Conditions
Keywords
post-concussion Syndrome, diagnosis of 7T MRI in post-concussion syndrom, S100b, mild head trauma
Brief summary
We aimed to conduct a prospective longitudinal interventionnal monocentric study to assess the ability of seven tesla MRI to detect diffuses axonal lesions in patients presenting a post concussional syndrom (PCS) at seven days about a mild traumatic brain injury (MTBI). Our first objective was to evaluate the diagnostic performance of seven tesla MRI runned at seven days after MTBI among patients presenting a PCS.
Detailed description
Among patients admitted in emergency care units in France for mild traumatic brain injury, 10 % will develop post concussionnal symptoms. The variability of the clinical presentation lead to a syndrome at the border of neurology, psychiatry and neuro-traumatology. Ninety per cent of these patients will have a favorable evolution in three to six months while ten per cent will have persistant symptoms : dizziness, headache, nausea, drowsiness, anxio-depressive symptoms, irritability, memory impairments, attentionnal disorders. This conduct to an additionnal medical and social cost (medical re-consultation in emergency services, pharmaceutical expenditure due to over medication, social recognition, deterioration of social and professionnal relationships …). The litterature data show the presence of diffuse axonal lesions (DAL) frequently observed in patients victims of MTBI. These lesions seemed to be correlate with the occurrence of post concussional symptoms. New brain imagery have lead to these discoveries but are not relevant in clinical routine (functionnal MRI, Diffusion Tensor Imaging, tractography). Computed Tomography is often normal and not able to detect these lesions. Standard MRI is not enough sensible for the detection of the DAL. Some autor shows alose that his sensibility decrease in time. These observations and encouraging results lead us to initiate a prospective interventionnal, longitudinal, pilot study monocentric using seven tesla MRI to evaluate its input in the detection of diffuse axonal lesions among patients presenting post concussionnal symptoms after a mild traumatic brain injury at day seven after they are admitted to our emergency service.
Interventions
OTHER7T MRI
Seven tesla brain MRI (7T MRI) at day 7 in patients suffering from post concussionnal symptoms after mild traumatic brain injury admitted to emergency departement of Poitiers CHU (University Hospital
Sponsors
Poitiers University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 72 Years
Healthy volunteers
No
Inclusion criteria
* Mild traumatic brain injury with glascow included between 13 and 15, with indication of scan * possibilty of performing an MRI at 7 days * Patient able to get to MRI at Day 7 * Free consentement to the study * Any measure of guardianship or curatorship , any link of subordination
Exclusion criteria
* Patient does not hospitalized about head trauma * Inhability to move out for run the seven day MRI * Contraindication for MRI * Patient having already consulted the emergency for head trauma requiring imaging * Patients with psychiatric troubles : bipolarity, panic trouble, depressive trouble, schizophrenia * Patient already enrolled in the study * History of brain, tumor or neurosurgery * Untreated or poorly treated chronic vertigo * Untreated or poorly treated chronic migraines * Claustrophobia * BMI \> 40 * Refusal of consent to take part of the study * No social welfare or inhability to benefit of it by a third party * Patients with enhanced protection : minor aged under 18 ; person with freedom restriction by justice decision or administrative ; homeliving in health or social establishment ; adult in legal protection * Pregnant and nursing women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Determine the diagnostic performance of 7 Tesla MRI performed of mild head trauma for the occurrence of post-concussion syndrome (PCS) | Day 7 | appearance of diffuse axonal lesions |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluate the S100b dosed at admission is correlated with diffuse axonal lesion | Day 7, Month 6, Month 12 | appearance of diffuse axonal lesion and S100b dosed at admission |
| Assess the quality of life of patients suffering for post-cocussion syndrome | Day 7, Month[6;12] | quality of life EQ-5D-5L questionary (score ranging from levels 1, 2, 3 (without problems) and levels 4,5 (with problems) and GOS-E scales (score ranging from 1.1 (good recovery) to 5 (death). |
| Correlation the association between the alteration of the anisotropy fraction (AF) and post-concussion syndrome on the MRI diffusion tensor (DTI) sequence | Day 7 | Focal alteration of AF data on a DTI sequence. |
| Evaluate the S100b dosed at admission is correlated with the occurrence of post concussion syndrome after a mild head injury. | Day 0 | Value of S100b dosed at admission |
| Compare the performance obtained on cognitive functioning as a function of cognitive reserve | Month 3 | Attentional Performance : Reaction times, correct, false responses and omissions = percentiles. 5 ≥ pathological. memory disorder : Verbal Learning Test : ≥ -1.65. pathological. bells test. Nb of total omission and a score of Left-Right omission are reported. Pathological \> 6 or a left-right score \> 2. Visual reproduction . immediate and delayed recall \< 7 pathological. Times to name, to read colours. Total errors are also converted in standard notes.Verbal fluencies Nber of words beginning with the letters P,R,S in 1 min. for each letter are summed. The result is z-scored. Perceptual Reasoning index : Block design and Picture Completion. Sum of the standard notes = percentile rank. Verbal Comprehension index : Similarities and Information. Sum of the standard notes = percentile rank. Working Memory index : Arithmetic and Digit Span. Sum of the standard notes = percentile rank.Processing speed index : Code. The standard note = twice to obtain the percentile rank. |
| Compare in patients the presence of anxio-depressive syndrome | Month 3 | Beck scale (Beck Depression Inventory Scale). The score runs from 0 to 39. 0-3 : no depressed mood; 4-7 : light depressed mood; 8-15 : mild depressed mood; 16 and more : severe depressed mood. |
| Correlation the association between the presence of a lesion on 7T MRI and the results of various neuropsychological tests. | Month 12 | Attentional Performance : Reaction times, correct, false responses and omissions = percentiles. 5 ≥ pathological. memory disorder : Verbal Learning Test : ≥ -1.65. pathological. bells test. Nb of total omission and a score of Left-Right omission are reported. Pathological \> 6 or a left-right score \> 2. Visual reproduction . immediate and delayed recall \< 7 pathological. Times to name, to read colours. Total errors are also converted in standard notes.Verbal fluencies Nber of words beginning with the letters P,R,S in 1 min. for each letter are summed. The result is z-scored. Perceptual Reasoning index : Block design and Picture Completion. Sum of the standard notes = percentile rank. Verbal Comprehension index : Similarities and Information. Sum of the standard notes = percentile rank. Working Memory index : Arithmetic and Digit Span. Sum of the standard notes = percentile rank.Processing speed index : Code. The standard note = twice to obtain the percentile rank. |
| Describe the diagnostic performance of the 7 T MRI and quality of life on the occurrence of a post-concussion syndrome | Month [3;6;12] | Rivermead Post Concussion Scale, ranging from 0 to 4 ; 0 = minimal , 4 = severy problem with 16 items results 64 points maximals (cut-off\>12) |
Countries
France
Contacts
Primary ContactJeremy GUENEZAN, Dr
Backup ContactMarika SAVATIER, Dr
Outcome results
None listed