COVID-19 Pneumonia
Conditions
Brief summary
This is an observational case-control study to evaluate COVID-19 vaccine effectiveness against hospitalisation with COVID-19 related conditions in St. Petersburg, Russia. Two sets of cases and control will be retrospectively analyzed to compare vaccination proportions and other characteristics to infer vaccine effectiveness from odds ratios. The first set of cases will be extracted from the data on hospitalisation of patients with COVID-19 to First Pavlov State Medical University of Saint-Petersburg hospitals, and controls will be patients hospitalised with other conditions. The second set of cases and controls will be based on patients referred to Medical Institute named after Berezin Sergey for computed tomography. Cases will be patients with positive SARS-CoV-2 status computed tomography confirmed pneumonia or patients referred to hospitalisation, and control will be patients without pneumonia and not referred to hospitalisation.
Interventions
BIOLOGICALCOVID-19 Vaccines
Gam-COVID-Vac EpiVacCorona COVIVAC
Sponsors
European University at St. Petersburg
Medical Institute named after Berezin Sergey
Ivan S Moiseev
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients hospitalized to clinics of First Pavlov State Medical University of Saint-Petersburg * Patients referred to Medical Institute named after Berezin Sergey for computed tomography * Available vaccination status
Exclusion criteria
\- Refusal to provide information for research purposes at the time of hospitalization or reference to computed tomography
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effectiveness of full vaccination against hospitalization with COVID-19 pneumonia | 3 months | Full vaccination effectiveness is calculated based on the odds ratio of vaccination proportions in cases and controls, adjusted for other patient characteristics. Full vaccination status is assigned after two weeks of the second dose for each vaccine separately. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effectiveness of partial vaccination against hospitalization with COVID-19 pneumonia | 3 months | Partial vaccination effectiveness is calculated based on the odds ratio of vaccination proportions in cases and controls, adjusted for other patient characteristics. Partial vaccination status is assigned after two weeks of the first dose for each vaccine separately. |
| Effectiveness of vaccination against hospitalization with COVID-19 pneumonia in different age groups | 3 months | Evaluate vaccine effectiveness in different age groups (\<20, 20-29, 30-39, 40-49, 50-59, 60-69, \>70) |
Countries
Russia
Outcome results
None listed