Inflammation
Conditions
Keywords
intravenous dexamethasone, inflammation, QoR15, drainage
Brief summary
This topic foe randomized prospective study.Detection of elderly patients with lunmbar spinal postoperative inflammatory substances in the blood and drainage of liquid level ,clear whether low-dose dexamethasone can inhibit the inflammation, the observation of elderly patients with lumbar spinal postoperative drainage star, to explor whether low-dose dexamthasone can reduce postoperative incision drainage, thus impove the postoprative drainage tube pull rate within three days, which in turn reduce because of the place a retrograde infection caused by drainage tube.
Detailed description
A total of 100 patients undergoing posterior lumbar disc fusion were randomly divided into control group (group C,n=50) and dexamethasone group (group D,n=50). Group D was given 0.15mg/kg dexamethasone (2ml) intravenously after anesthesia induction. Group C was also intravenously injected with 2ml normal saline after anesthesia induction.On this basis, monitor the main results and secondary results
Interventions
Intravenous injection after induction of anesthesia Injection 0.15mg/kg dexamethasone (2ml)
DRUGNormal saline
2ml of normal saline was injected intravenously after induction of anesthesia
Sponsors
General Hospital of Ningxia Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients ≥65years of age * American Society of Anesthesiologists (ASA) physical status 2-4 * Elective or expedited non-cardiac surgery of at least 2 hours dura- tion under general anaesthesia * Requiring a hospital stay of at least one postoperative night * A surgical skin incision \>5 cm in length or multiple incisions with a total incision length of \>5 cm
Exclusion criteria
· * Poorly controlled diabetes (HbA1c\>9.0%) * Endovascular procedure with a small (\<5 cm length) skin incision Ophthalmic surgery * Planned dexamethasone (or other corticosteroid) therapy (eg, history of intractable PONV, maxillofacial surgery, intracranial neurosurgery) * Recent (\<2 weeks since end of treatment) infective episode requir- ing treatment with antibiotics * Chronic antibiotic therapy (eg, for bronchiectasis, cystic fibrosis etc)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the change of drainage fluid volume | 6 hours after surgery， the morning of 1, 2, and 3 days after surgery | Drainage fluid （ml）was collected and the volume of drainage fluid was recorded Until the drainage tube was pulled out, |
| the change of Inflammatory mediators in the drainage fluid | 6 hours after surgery， the morning of 1, 2, and 3 days after surgery | CRP(mg/ L) in postoperative drainage fluid was observed |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the change of blood inflammatory mediators | 6 hours after surgery， the morning of 1, 2, and 3 days after surgery | Fasting blood was collected from each enrolled patient preoperatively, 6 hours after surgery and on the morning of 1, 2, and 3 days after surgery Fasting blood, blood samples were centrifuged (1500r/min, 15min) and serum was separated and placed in -80℃ deep low temperature refrigerator for measurement. The observation technique After the blood CRP(mg/l) |
| the change of blood routine white blood cell count | 6 hours after surgery， the morning of 1, 2, and 3 days after surgery | Fasting blood was collected from each enrolled patient preoperatively, 6 hours after surgery and on the morning of 1, 2, and 3 days after surgery Fasting blood, blood samples were centrifuged (1500r/min, 15min) and serum was separated and placed in -80℃ deep low temperature refrigerator for measurement. The observation technique After the blood blood routine white blood cell count |
Countries
China
Outcome results
None listed