Colorectal Cancer, Gastric Cancer
Conditions
Keywords
gut microbiota, gut barrier integrity, enteral immunonutrition, gastric cancer, colorectal cancer
Brief summary
Enteral immunomodulating nutrition modifies the gastrointestinal microbiota as well as improves the intestinal barrier integrity in patients with gastric and colorectal cancer in the perioperative period. As a consequence, it contributes to the reduction of the incidence of postoperative complications and diarrhea, which is a side effect of anti-cancer treatment often used preoperatively in this group of cancers.
Interventions
DIETARY_SUPPLEMENTImpact Oral Nestlé Health Science, Cubitan® Nutricia, Nutridrink® Nutricia, Resource 2.0 Nestlé Health Science
Gastric and colorectal cancer patients will receive 1 bottle of immunonutrition or standard nutrition for 10 days. The aims of this study is to assess the effects of these immunonutrition on gut microbiota, intestinal permeability as well as inflammation of intestines in gastric and colorectal cancer patients.
Sponsors
Medical University of Gdansk
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* age \>18 y.o. * patients with gastric or colorectal cancer * patients treated in Department of Surgical Oncology, Medical University of Gdańsk * patients' agreement to take part in this study
Exclusion criteria
* age \<18 y.o. * other types of cancer than gastric/colorectal cancer * the presence of inflammatory bowel disease * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The impact of immunonutrition on gut microbiota in gastric and colorectal cancer patients. | at baseline and after 7 and 10 days | The composition of gut microbiota (bacteria and fungi) will be assessed from stools. The amounts of bacteria/fungi will be presented using bioinformatics tools and there is no precisely described units (only the total number). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The impact of immunonutrition on intestinal permeability in gastric and colorectal cancer patients. | at baseline and after 7 and 10 days | The ratio lactulose/mannitol will be described to assess intestinal permeability. There is no units. Only ratio of two numbers. |
| The impact of immunonutrition on intestines in gastric and colorectal cancer patients. | at baseline and after 7 and 10 days | The calprotecin will be assessed. The unit is μg/g. |
Outcome results
None listed