Hypercapnia
Conditions
Brief summary
The aim of this study is to determine whether there are any changes in the carbon dioxide partial pressure in medical staff while wearing a filtering face piece (FFP) 2 or FFP3 mask. Furthermore, changes in the capillary oxygen partial pressure, the subjective respiratory effort and the breathing rate are measured.
Detailed description
In the fight against the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), the personal protective equipment (PPE) of medical staff plays a special role. Since the pathogen can be transmitted via droplets, particle-filtering half masks (filtering face piece - FFP) are a substantial part of the PPE. The current data indicate that there may be an increase in the carbon dioxide partial pressure (PcCO2) in the blood when wearing an FFP2 / 3 mask during routine medical activity. The aim of this prospective cross-over study is to compare the PcCO2 measured by capillary blood sampling from medical staff while wearing an FFP2 or FFP3 mask. The PcCO2 determined without a mask serves as a reference value. While no mask is worn, the PcCO2, the subjective respiratory effort, the breathing rate and the capillary oxygen partial pressure (PcO2) is measured. The study participants then wear an FFP2 or FFP3 mask for one hour, and the same parameters are collected. Subsequently, the participant switches to an FFP3 or FFP2 mask, and the last measurement is conducted after one hour.
Interventions
OTHERNo mask
The participant is asked to wear no mask for 10 minutes.
DEVICEFiltering face mask 2 (FFP2)
The participant is asked to wear a FFP2 mask for 1 hour during work.
DEVICEFiltering face mask 3 (FFP3)
The participant is asked to wear a FFP3 mask for 1 hour during work.
Sponsors
Medical University of Vienna
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
1. arm: starts with no mask - FFP2 mask - FFP3 mask 2. arm: starts with no mask - FFP3 mask - FFP2 mask
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* medical staff working at the Vienna General Hospital * oral and written consent to take part voluntarily in this trial
Exclusion criteria
* hypersensitivity / allergy against Nonylvanillamid, Nikotinsäure-beta-butoxyethylester or other component of Finalgon Salbe * not Coronavirus disease-19 vaccinated * pregnancy * breastfeeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of PcCO2 | 1. measurement after 10 minutes without mask, 2. measurement after 1 hour with mask (FFP2/3), 3. measurement after 1 hour with mask (FFP3/2) | Change of capillary carbon dioxide partial pressure (PcCO2) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of PcO2 | 1. measurement after 10 minutes without mask, 2. measurement after 1 hour with mask (FFP2/3), 3. measurement after 1 hour with mask (FFP3/2) | Change of capillary oxygen partial pressure (PcO2) |
| Respiratory rate | 1. measurement after 10 minutes without mask, 2. measurement after 1 hour with mask (FFP2/3), 3. measurement after 1 hour with mask (FFP3/2) | Number of breaths per minute |
| Exertion score | 1. measurement after 10 minutes without mask, 2. measurement after 1 hour with mask (FFP2/3), 3. measurement after 1 hour with mask (FFP3/2) | Participant subjective score: How difficult is it for you to breathe at the moment?; scale from 1-5, 1= easy, 2= rather easy, 3= moderate, 4= rather hard, 5= hard |
Countries
Austria
Outcome results
None listed