Arterial Switch Operation
Conditions
Brief summary
The aims of this study are to 1. Identify the early and midterm outcomes in terms of mortality and reoperation of the arterial switch operation (ASO). 2. Identifying the influence of coronary artery anomalies on the in-hospital and post-discharge prognosis after ASO. 3. Evaluate the predictors for neoaortic valve regurgitation after ASO. 4. Explore the risk factors for neopulmonary artery stenosis after ASO.
Detailed description
This study will enroll participants with transposition of the great arteries (TGA) and double outlet right ventricle with subpulmonary ventricular septal defect (VSD) (Taussig-Bing anomaly, TBA). The cardiac structure and function will be evaluated by multimodal imaging including transthoracic echocardiographic examination, stress echocardiography, cardiac computed tomography scan, cardiovascular magnetic resonance imaging. And the study aimed to: 1. Identify the early and midterm outcomes in terms of mortality and reoperation of the arterial switch operation (ASO) in participants with transposition of the great arteries (TGA) and double outlet right ventricle with subpulmonary ventricular septal defect (VSD) (Taussig-Bing anomaly, TBA). 2. Identifying subclinical coronary abnormalities and silent myocardial ischemia by multimodel Imaging, further determine the influence of coronary artery anomalies on the in-hospital and post-discharge prognosis in participants with TGA and TBA after ASO. 3. Evaluate the time course and predictors for neoaortic root dilatation and neoaortic valve regurgitation in participants with TGA and TBA after ASO by multimodel Imaging. 4. Assess the structure of the right ventricular outflow tract and neopulmonary artery in participants with TGA and TBA after ASO by multimodel Imaging, and explore the incidence and risk factors for neopulmonary artery stenosis.
Interventions
None listed
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Shanghai Zhongshan Hospital
Henan Provincial People's Hospital
Wuhan Asia Heart Hospital
Guangdong Provincial People's Hospital
Xie Mingxing
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
·Participants with the diagnosis of TGA or TBA underwent ASO.
Exclusion criteria
* Patients with various forms of TGA undergoing Réparation à l'Etage Ventriculaire procedure * Patients with various forms of TGA undergoing Rastelli procedure * Patients with various forms of TGA undergoing Nikaidoh procedure * Patients with various forms of TGA undergoing Fontan operation * Patients with various forms of TGA undergoing atrial repair (Mustard or Senning) operations * ASO is used as a corrective therapy for prior operations.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| All cause mortality | Ten years | Number of participants with all cause mortality after ASO |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cardiac caused mortality | Ten years | Number of participants with cardiac caused mortality after ASO |
| All cause reoperation | Ten years | Number of participants with all cause reoperation after ASO |
| Right-ventricular outflow tract obstruction and pulmonary branch stenosis | Ten years | Degree of more than moderate right-ventricular outflow tract obstruction in millimetre of mercury, degree of pulmonary branch stenosis in millimetre of mercury |
| Neoaortic valve regurgitation | Ten years | Vena contracta width of neoaortic valve regurgitation in milimetre, ratio of Jet width/LVOT width in percentage |
Contacts
Primary ContactLi Zhang, PhD
Outcome results
None listed