Bone Loss, Critical Illness, Kidney Injury, Muscle Loss
Conditions
Brief summary
This observational study aims to assess kidney function through direct glomerular filtration rate (GFR) using iohexol clearance, compared to estimated GFR based on creatinine and cystatin C equations. Kidney function will also be evaluated through renal fibrosis biomarkers. Kidney function will be correlated to body composition, muscle turnover biomarkers, and bone micro-architecture.
Detailed description
The investigators developed a post-ICU clinic where complications of the post-intensive care syndrome are detected. Muscle function is assessed by clinical testings, muscle strength measurement. Body composition is measured by electrical bioimpedance. Bone mass is assessed using dual-energy radiographic absorptiometry. It is well known that ICU survivors experience a loss of muscle mass. This can lead to misinterpretation of estimated GFR based on creatinine equations. The aim of the present study is to assess the evolution of kidney function after a prolonged stay in ICU, using GFR equations based on cystatin C, and to compare it to measured GFR using iohexol clearance. The second aim is to explore the evolution of bone and muscle health in these patients.
Interventions
OTHERone-year follow-up
patients will be followed during the year after ICU discharge, in order to assess kidney function, and muscle and bone health
Sponsors
University of Liege
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients surviving an ICU stay of at least 7 days * patients who experienced acute kidney injury (KDIGO criteria) during ICU stay
Exclusion criteria
* chronic kidney injury with dedicated follow-up before ICU admission * chronic extrarenal epuration * kidney transplant * allergy to iohexol * iodinated contrast allergy * refusal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| measured GFR | between day 0 and day 7 after ICU discharge | plasma clearance of iohexol |
| estimated GFR | between day 0 and day 7 after ICU discharge | cystatin C based CKD-EPI equation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| urine concentration of renal fibrose biomarkers | between day 0 and day 7 after ICU discharge | urine measurement of TGF-β concentration |
| blood concentration of muscle turnover markers | between day 0 and day 7 after ICU discharge | blood measurement of myostatin concentration |
| bone micro-architecture | between day 0 and day 7 after ICU discharge | high resolution peripheral quantitative computed tomography (HRpQCT) images acquisition |
Countries
Belgium
Outcome results
None listed