Evaluation of Sticky Bone With or Without EDTA for Treatment of Gingival Recession

Evaluation of Sticky Bone With or Without EDTA Root Surface Biomodification for Treatment of Gingival Recession: Randomized Controlled Clinical Study

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04980066

Enrollment

Registered

2021-07-28

Start date

2021-08-03

Completion date

2024-09-30

Last updated

2024-04-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingival Recession

Keywords

i-PRF, EDTA

Brief summary

Gingival recession is a common clinical finding in periodontal disease which is frequently associated with esthetic concerns, root hypersensitivity, and root caries. Many surgical therapeutic approaches have been developed to predictably obtain root coverage of gingival recession defects. Injectable PRF (I-PRF) is the liquid form of PRF. I-PRF is a bioactive agent obtained by low-speed centrifugation, and it has the capacity to stimulate tissue regeneration. At high concentrations, PRF may stimulate the secretion of several growth factors and trigger fibroblast migration. I-PRF is generally used in regenerative treatments, with good outcomes. Ethylenediaminetetraaceti acid (EDTA) is a chelating agent that could enhance the attachment of connective tissue to the root surface by exposing collagen and, as a consequence, enhance root coverage. EDTA works at neutral pH, and this property has been reported to preserve adjacent tissue vitality. The present study will be carried out to evaluate the effect of sticky bone with or without EDTA root surface biomodification for treatment of gingival recession.

Interventions

PROCEDURESticky bone and EDTA

treatment using Sticky bone after EDTA root surface biomodification

PROCEDURESticky bone

treatment using Sticky bone

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Miller I/II isolated maxillary recession defects. * No abrasion, caries, or cervical restorations and presence of identifiable cementoenamel junction (CEJ). * No occlusal interferences. * Full-mouth plaque index (PI) and gingival index (GI) scores of \< 1. * Non-smokers.

Exclusion criteria

* Pregnant patients * Presence of systemic disease or taking medication that interfere with periodontium

Design outcomes

Primary

Measure	Time frame	Description
clinical evaluation of root coverage	6 months	the percentage of root coverage will be calculated in millimeter

Countries

Egypt

Contacts

Primary ContactDalia R Issa, PhD

dalia_rasheed@hotmail.com01007753636

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026