Cardiac Surgery, Cardiopulmonary Bypass, Renal Transplant Recipient
Conditions
Keywords
cardiac surgery, renal transplant recipient, renal function, acute kidney injury, major adverse kidney events
Brief summary
In this retrospective study, the authors assess long term renal outcome in renal transplant recipients after cardiac surgery with cardiopulmonary bypass, and research factors associated with poor long term renal outcome.
Detailed description
Post-operative mortality after cardiac surgery is increased in renal transplant recipients, compared with general population of cardiac surgery, or with kidney transplant recipients not undergoing cardiac surgery. If the survival of this specific population is now well studied, the long-term renal outcome is much less studied. Previous studies show a trend for increased risk of allograft dysfunction and need for permanent dialysis. This study proposes to compare long term renal outcome between renal transplant recipients and non-renal transplant recipients.
Interventions
OTHERstandard of care
retrospective study : standard of care
Sponsors
University Hospital, Bordeaux
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
for Renal Transplant Recipients group: * Previous renal transplantation * Who underwent cardiac surgery with CPB Inclusion Criteria for Non Renal Transplant Récipients group: * No previous renal transplantation * Who underwent cardiac surgery with CPB * Apparied with Renal Transplant récipients with the 5 following criteria : age, sex, previous diagnosis of diabete, type of cardiac surgery (isolated coronary artery bypass graft, valvular surgery, aorta surgery, combined surgery), best glomerular filtration rate with CKD-EPI formula at +/- 15 ml/min, in the 3 pre-operative months
Exclusion criteria
* Patients requiring mechanical circulatory support (Extracorporeal Membrane Oxygenation) * Pre-operative permanent dialysis * Aorta dissection extended to renal arteries * Non-elective surgery for infective endocarditis * Previous hepatic, pancreatic or cardiac transplantation * Death in the 30 first days after cardiac surgery * Patient not meeting the inclusion criteria
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Long-term renal outcome | 12 months after surgery | Proportion of patients meeting a composite criterion : death or permanent dialysis or doubling the baseline serum creatinine value |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Glomerular Filtration Rate (GFR) | 30 days after surgery | Glomerular Filtration Rate (GFR) calculated with CKD-EPI formula |
| Vital status | 12 months after surgery | Mortality after surgery |
| Major Adverse Kidney Events | Up to 12 months after surgery | Major Adverse Kidney Events defined by new receipt of Renal replacement therapy (RRT), or Acute Kidney Injury (AKI) episodes with persistent renal dysfunction and final serum creatinine value before hospital discharge ≥ 200 % of the baseline serum creatinine |
Countries
France
Outcome results
None listed