Diagnosis, Incidence and Consequences of PACU-Delirium

Diagnosis, Incidence and Consequences of Postoperative Delirium in Elderly Patients in the Post-anaesthetic Care Unit

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04978870

Acronym

PADE-DIC

Enrollment

450

Registered

2021-07-27

Start date

2021-07-29

Completion date

2024-08-01

Last updated

2025-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive Decline, Elderly Patient, Postoperative Delirium

Keywords

Post-anesthetic care, Cognitive recovery, Delirium

Brief summary

This study aims to 1. determine sensitivity and specificity of the Confusion Assessment Method for Postanesthesia Care Unit (CAM-PACU) 2. examine the effect of postanesthesia care unit delirium (PACU delirium) on the emergence of later onset postoperative delirium (POD) as well as cognitive recovery until one month postoperatively

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

* planned surgery in the near future * surgery time at least 60min

Exclusion criteria

* intracranial surgery * expected postoperative transfer to ICU and stay exceeding 24h * length of postoperative stay in hospital below 24h * insufficient German language skills * current alcohol or drug misuse * manifest mental illness

Design outcomes

Primary

Measure	Time frame	Description
Group 1: Sensitivity and specificity of Confusion Assessment Method - Postanesthetic Care Unit (CAM-PACU)	15-240 minutes postoperatively	in reference to International Classification of Diseases-Version 10 (ICD-10)
Group 2: postoperative delirium after discharge from Postanesthetic Care Unit	0-5 days postoperatively	3D CAM and/or medical record

Secondary

Measure	Time frame	Description
re-test reliability	15-240 minutes postoperatively	CAM-PACU
cognitive performance	before, 7 and 30 days postoperatively	Montreal Cognitive Assessment (MoCA, 0-30 points, higher score = better outcome), Cognitive Telephone Screening Instrument (COGTEL), Patient Reported Outcomes Measurement Information System (PROMIS Neuro QoL)
postoperative complications	30 days postoperatively	European Perioperative Clinical Outcome (EPCO) definitions; Standardised Endpoints in Perioperative Medicine - Core Outcome Measures in Perioperative and Anaesthetic Care (Step-COMPAC) definitions
feasibility of delirium screening by questioning of medical staff	before, 3 and 12 months after implementation of CAM-PACU	self-designed questionnaire

Countries

Germany

Outcome results