Research on the Application and Mechanism of New Biological Probes in Biomedicine

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04977739

Enrollment

737

Registered

2021-07-27

Start date

2021-08-03

Completion date

2022-07-25

Last updated

2022-08-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Diseases, Cardiovascular Diseases, Digestive System Diseases, Endocrine System Diseases, Immune System Diseases, Infectious Diseases, Metabolic Diseases, Nervous System Diseases, Respiratory System Diseases, Tumors, Urinary System Diseases

Brief summary

Fluorescence is one of the most commonly used research and detection techniques in the field of biomedical science. The characteristics of fluorescent probe directly affect the performance and application of fluorescence analysis and imaging. Aggregation-Caused Quenching has limited the application of traditional fluorescent probes to some extent. This project intends to systematically evaluate the detection efficiency of new methods through the detection of biomarkers in clinical samples and the comparison with the detection methods of traditional biomarkers, so as to provide theoretical and experimental basis for the establishment of fast and simple biomarker detection technologies with new biological probes.

Interventions

DIAGNOSTIC_TESTNo intervention

No intervention

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Sign the informed consent form voluntarily. * Age 18-70 years old. * High expression (positive) group: The results of multiple laboratory tests indicate that the marker is higher than the normal range. * Low expression (negative) healthy volunteer group: those with no underlying diseases and no abnormalities in the physical examination. * Have routine examination to check the remaining body fluid samples, and the body fluid samples are not contaminated.

Exclusion criteria

* Accompanied by other inflammations. * The data of the subject is not complete, or the collection of cases is incomplete due to other reasons. * The researcher judged that it was not suitable to participate in this research.

Design outcomes

Primary

Measure	Time frame
signal intensity of the probes	one day

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026