Intensive Care Unit Syndrome
Conditions
Brief summary
This prospective interventional randomized control study was conducted on forty patients with respiratory failure; all patients were intubated and mechanically ventilated for at least three days. Twenty patients received high protein intake using whey protein, with daily follow-up of the blood sugar level, serum electrolytes, and chemistry. ICU outcome regarding food intolerance, 30-day mortality, length of MV and ICU-stay was recorded
Interventions
DIETARY_SUPPLEMENTWhey protein
Patients were randomly divided into two groups: Group (A): Enteral feeding with normal protein intake ( 1.0 gm pin /kg/day ) Group (B): Enteral feeding with high protein intake ( 1.5- gm open /kg/day ) -Patient's- nonprotein- caloric intake was calculated according to REE :(25xactual body weight in kg ) and received it as follow : 1/2 the calculated amount of caloric intake in DAY 1 3/4 of the calculated amount of caloric intake in DAY 2 -Full calculated caloric amount in DAY 3 This regimen was followed long as the patient was tolerating the amount of feeding, and in case of intolerance: The volume of feeding boluses was decreased or Increase the time interval between boluses or IV metoclopramide or erythromycin was given
Sponsors
Cairo University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Age \>18 years * Mechanically ventilated patients (for three days or more )
Exclusion criteria
* Age \< 18 years old * Contraindication for enteral nutrition (gut ischemia, obstruction, or perforation) * Expected intolerance for enteral nutrition (paralytic ileus) * Inability to start enteral nutrition within 24-hours(i.e. surgery or other interventions) * Short bowel syndrome * Hemodynamic instability ( i.e shock state, need for vasopressors ) * Child C liver cirrhosis or acute liver failure * Dialysis dependency
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of high protein intake on glycemic control | up to 7 days | measurements of blood glucose levels regularly after high protein intake |
| Effect of high protein intake on serum electrolytes | up to 7 days | measurements of Na, K, Mg, phosphorous and calcium levels regularly after high protein intake |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effect of high protein intake on ICU outcome | up to 7 days | ICU outcome includes ICU survival , mechanical ventilation , food intolerance |
Countries
Egypt
Outcome results
None listed