Relationship of Retinal and Visual Cortex Structure and Visual Acuity After Congenital Cataract Surgery

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04976608

Enrollment

Registered

2021-07-26

Start date

2021-06-16

Completion date

2021-12-30

Last updated

2021-07-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Congenital Cataract

Keywords

amblyopia, MRI, SD-OCT, visual acuity, retinal structure, visual cortex structure

Brief summary

To evaluate the influence of the visual acuity after congenital surgery on the retinal and visual cortex structure.

Detailed description

According to the visual acuity after congenital cataract surgery, 30 patients are divided into 3 groups.SD-OCT and MRI were used to measure the parameters of the retina and the visual cortex, to compare the differences between different groups, and to analyze the relationship between the structure of the retina and the visual cortex and visual acuity.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

4 Years to 60 Years

Healthy volunteers

Inclusion criteria

* age of 4-60 years * Congenital cataract surgery is planned * The operation was successful without any complications * Can cooperate well with OCT and MRI examinations

Exclusion criteria

* Intraoperative and postoperative complications include glaucoma, retinal, corneal, or refractive medium diseases * Behavioral, cognitive impairment * Developmental delay

Design outcomes

Primary

Measure	Time frame	Description
Macular thickness	2021.12.30	Scan the 3.0mm diameter ETDRS ring area in the macular area with SD-OCT.
Subfoveal choroidal thickness	2021.12.30	Scan the Subfoveal choroid in enhanced scan mode with SD-OCT.
Retinal nerve fiber layer thickness	2021.12.30	Scan concentric circles with a length of 3.4mm and a diameter ranging from 2.5mm to 4.0mm in 12 directions centered on the optic disc with SD-OCT.
The volume of the lateral geniculate body	2021.12.30	Measure the volume of the lateral geniculate body by T1 phase scan of MRI
The volume of the brodmann 17,18,19 area	2021.12.30	Masure the volume of the brodmann 17,18,19 area by T1 phase scan of MRI
The FA of the white matter fiber bundle	2021.12.30	Measure the Fraction Anisotropy of the white matter fiber bundle related to visual signal transduction by DWI scan of MRI

Countries

China

Contacts

Primary ContactYune Zhao

zyehzeye@126.com8613819707056

Backup ContactJiayan Fang

1132093186@qq.com8615957793328

Outcome results