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Patogenic Mutation in 5 Genes

Genomic Landscape of APC, KRAS, TP53, PIK3CA, and MLH1 in Colorectal

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04976439
Enrollment
22
Registered
2021-07-26
Start date
2021-05-01
Completion date
2021-06-14
Last updated
2021-07-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

APC Gene Mutation, Colorectal Cancer, KRAS Mutation-Related Tumors, MLH1 Gene Mutation, PIK3CA Gene Mutation, TP53 Gene Mutation

Keywords

next-generation sequencing, colorectal cancer, indonesia population, co-occurring mutation

Brief summary

This is a pathogenic mutation profile of colorectal patients specifically in 5 genes, i.e. APC, TP53, PIK3CA, KRAS, and MLH1. Single nucleotide variants identified were synchronized with patients' characteristics.

Interventions

OTHERco-occuring mutation

APC, TP53, PIK3CA, KRAS APC, TP53, PIK3CA, MLH1 APC, TP53, PIK3CA, KRAS, and MLH1 APC, TP53, PIK3CA

Sponsors

Dr Cipto Mangunkusumo General Hospital
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* FFPE samples fullfilling purity criterion and pass quality control

Exclusion criteria

* none

Design outcomes

Primary

MeasureTime frameDescription
Description of clinical characteristicsJanuary 2017 - June 2021Age, gender
Description of tumor natureJanuary 2017 - June 2021grade, stage, lymphovascular invasion, tumor location
Description of survivalJanuary 2017 - June 2021Median of life expectancy

Countries

Indonesia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026