Coronary Artery Disease
Conditions
Keywords
Fractional Flow Reserve, Resting Full-Cycle Ratio
Brief summary
The DISENGAGE@rest study is a prospective registry carried out at Federico II University of Naples with the aim to evaluate the influence of the guiding catheter engagement within the coronary ostium on both FFR and non-hyperaemic pressure ratios values (such as Pd/Pa and the Resting Full-cycle Ratio -RFR), as well as the corresponding clinical impact on decision-making strategies. Consecutive patients with at least one intermediate stenosis (40%-90% by visual estimation) in any of the 3 main coronary arteries will be included.
Interventions
DIAGNOSTIC_TESTFractional Flow Reserve
Comparison between FFR and NHPR before and after guiding catheter disengagement
Sponsors
Federico II University
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \> 18 years; * Patients provides informed consent; * Documented coronary artery disease: * chronic coronary syndromes * acute coronary syndromes presenting with at least one stenosis with indication for invasive functional assessment.
Exclusion criteria
* Patients unable to provide informed consent; * Pregnant women; * Any contraindication to perform angiographic study or functional evaluation with pressure wire; * Patients with aorto-ostial stenosis * Target vessel diameter \< 2mm
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differences between FFR before and after guiding catheter disengagement | 10 minutes | Evaluate the influence of the guiding catheter engagement within the coronary ostium on FFR values. |
| 1. Differences between NHPR before and after guiding catheter disengagement | 10 minutes | Evaluate the influence of the guiding catheter engagement within the coronary ostium on NHPR values |
Countries
Italy
Outcome results
None listed