Prevenetion of Intrauterine Adhesions by Hyaluronic Acid Gel
Conditions
Keywords
retained placenta, operative hysteroscopy, intrauterine adhesions, hyaluronic acid
Brief summary
Women undergoing operative hysteroscopy for removal of retained placenta after delivery will be randomized into two groups. 1. study group - immediately after operative hysteroscopy 5 ml hyaluronic acid gel will be injected into uterine cavity 2. control group - no injection 4-8 weeks after operative hysteroscopy, participants will undergo diagnostic hysteroscopy with no anesthesia , as a part of routine evaluation after removal of retained placenta in Israel. during diagnostic hysteroscopy the uterine cavity will be evaluated and the presence of adhesions and severity of adhesions will be recorded.
Interventions
DRUGIntrauterine injection of hyaluronic acid
operative hysteroscopy - as a part of treatment in cases with retained placenta after delivery diagnostic hysteroscopy - as a routine evaluation after removal of placenta
Sponsors
Barzilai Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Women undergoing hysteroscopic removal of retained placenta after delivery
Exclusion criteria
* Known adverse reaction or allergy to hyaluronic acid History of intrauterine adhesions Acute pelvic inflammatory disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| any adhesions | 4-8 weeks after intervention | presence of any adhesions in uterine cavity during diagnostic hysteroscopy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| adhesion scorring | 4-8 weeks after intervention | American Fertility Society score for intrauterine adhesions |
Countries
Israel
Outcome results
None listed