Cervical Cancer, Uterine Cervical Cancer, Uterine Cervical Neoplasm
Conditions
Brief summary
Most uterine cervical high-risk human papillomavirus (HPV) infections are transient, with only a small fraction developing into cervical cancer. Family aggregation studies and heritability estimates suggest a significant inherited genetic component. Candidate gene studies and previous genome-wide association studies (GWASs) report associations between the HLA region and cervical cancer. Adopting a genome-wide approach, we aimed to establish an early warning model for a high-risk population of cervical cancer.
Interventions
None listed
Sponsors
Women's Hospital School Of Medicine Zhejiang University
Obstetrics & Gynecology Hospital of Fudan University
Qilu Hospital of Shandong University
Wuhan Central Hospital
Third Military Medical University
Xiangyang Central Hospital
Shenzhen Second People's Hospital
Huazhong University of Science and Technology
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
25 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* (1) Case group a) Aged 25-75 years. b) Han nationality. c) Patients with cervical cancer or cervical precancerous lesions above CIN2 diagnosed by biopsy or postoperative pathological diagnosis. * (2) Control group: a) Aged 25-75 years. b) Han nationality. c) No family history of cervical cancer or precancerous lesions. d) The results of TCT examination showed no abnormality.
Exclusion criteria
* (1) suffering from other neoplastic diseases. * (2) pregnant women. * (3) those with a history of bone marrow transplantation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Significant loci of genetic variation | 2 | The impact of genetic variance on predisposition to cervical cancer |
Countries
China
Contacts
Primary ContactDing Ma, MD, PhD
Outcome results
None listed