Heart Transplant
Conditions
Brief summary
The aims of this study are to 1. Assess the preoperative and postoperative atrial and ventricular structure and function comprehensively in heart transplantation; 2. Explore the early, accurately and non-invasively indicators for evaluating myocardial fibrosis in end-stage heart failure, as well detecting acute rejection (AR),coronary allograft vasculopathy(CAV) and adverse clinical events in heart transplant patients by using conventional and the advanced echocardiography.
Detailed description
This study will enrolled 1000 HT patients and 500 healthy controls, and the cardiac structure and function will be evaluated by ultrasound multimodal imaging. And the study aimed to 1. Assess the preoperative and postoperative atrial and ventricular structure and function comprehensively in heart transplantation; 2. Explore the early, accurately and non-invasively indicators for evaluating myocardial fibrosis in end-stage heart failure, as well detecting acute rejection(AR),coronary allograft vasculopathy(CAV) and adverse clinical events in heart transplant patients by using conventional and the advanced echocardiography.
Interventions
None listed
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Shanghai Zhongshan Hospital
Henan Provincial People's Hospital
Wuhan Asia Heart Hospital
Guangdong Provincial People's Hospital
Xie Mingxing
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy volunteers
Exclusion criteria
* had history of hypertension, diabetes mellitus, renal failure or other organic diseases based on physical examinations, biochemical tests, electrocardiogram, echocardiography
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Using Image-Pro Plus 6.0 software to measure myocardial fibrosis | the measurement of myocardial fibrosis up to 1 year after heart transplant | The extent of myocardial fibrosis of the myocardial tissue from the removed heart during heart transplant was measured by Image-Pro Plus 6.0 software up to 1 year after heart transplant |
| All cause death after the inclusion of the study | All cause death happened after inclusion of this study, up to 5 years | All cause death after HT was obtained via telephone interview with family members; contact with his/her physicians; or hospital records every year |
| Acute rejection after the inclusion of the study | Acute rejection happened after inclusion of this study, up to 5 years | Acute rejection after the inclusion of the study was obtained at regular intervals via telephone interview with the patient, or if deceased, with family members; contact with his/her physicians; or hospital records every year |
| Cardiac allograft vasculopathy after the inclusion of the study | Cardiac allograft vasculopathy happened after inclusion of this study, up to 5 years | Cardiac allograft vasculopathy after the inclusion of the study was obtained at regular intervals via telephone interview with the patient, or if deceased, with family members; contact with his/her physicians; or hospital records every year |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Major adverse cardiac events after the inclusion of the study | Major adverse cardiac events happened after inclusion of this study，up to 5 years | Major adverse cardiac events after the inclusion of the study was obtained at regular intervals via telephone interview with the patient, or if deceased, with family members; contact with his/her physicians; or hospital records every year |
Contacts
Primary ContactLi Zhang, PhD
Outcome results
None listed