Thyroid Fibrosis
Conditions
Brief summary
Gluten sensitivity is the most common auto-immune disease associated with auto-immune thyroiditis. This association is through elevated anti-Tissue transglutaminase (Anti-tTG) levels both in Celiac disease and thyroiditis. In our study we tried to find if there is any correlation in between Anti-tTG and degree of fibrosis in thyroid tissue (Post-operative specimen).
Detailed description
Most common auto-immune disease associated with Celiac disease is autoimmune thyroiditis. This association in between Celiac disease and aout-immune thyroiditis is related with asymptomatic rise in anti-tTG levels. In our study, we planned to show that if there is any correlation of thyroiditis related fibrosis in thyroid tissue with anti-tTG IgA ( immune-globulin A) and IgG (immune-globulin G).
Interventions
OTHERMeasuring of fibrosis in thyroid specimen and measuring of Anti-tTG in serum samples
Examination of pathology specimen and laboratory measuring
Sponsors
Diskapi Yildirim Beyazit Education and Research Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 88 Years
Healthy volunteers
No
Inclusion criteria
* Thyroiditis patients operated for any indication
Exclusion criteria
* Patients with known IgA deficiency
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Amount of fibrosis in thyroid tissue and measured level of anti-tTG levels in serum | one day after operation | Degree of fibrosis was defined after painting of slides with masson trichrome as absent, mild, moderate semi-quantitatively. |
| Measurement of Anti-tTG levels in serum | one day after operation | Amount of serum Anti-TG in IU/mL |
Countries
Turkey (Türkiye)
Outcome results
None listed