Infertility, Female
Conditions
Brief summary
GnRH agonist triggering is used during ART in order to reduce the risk of OHSS. Some studies described that in up to 5% of the cycles triggered with GnRH agonist, a lack of respone or suboptimal response was displayed. The investigators aim to asses the possibility to predict the respone to ovulation triggering by the response to decapeptyl in the follicular phase of the same cycle.
Detailed description
The investigators will use Decapeptyl on day 2 of menstruation followed by antagonist protocol. Hormonal proflie including E2, P, LH, FSH will be measured. LH surge and the rest of the hormonal profile will be compared to day after ovulation triggering.
Interventions
OTHERDecapeptyl
diagnosis of predictio value
Sponsors
Assaf-Harofeh Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 41 Years
Healthy volunteers
No
Inclusion criteria
* patients that undergo fertility preservation * patients planned to freeze embryos due to PGT or surrogacy --patients at high risk for OHSS
Exclusion criteria
* Poor ovarian response * known hypothalamic- pituitary dysfunction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The response to GnRH triggering | One treatment cycle (each cycle is 28 days) for each participant (up to 28 days). | LH levels 10-12 hours after decapeptyl trigger, number of mature oocytes |
Countries
Israel
Contacts
Primary ContactSarit Avraham, Dr
Outcome results
None listed