Cigarette Smoking-Related Carcinoma
Conditions
Brief summary
This study examines how electronic (e)-cigarette use impacts the body, by studying both users and non-users of e-cigarettes. Early evidence indicates that e-cig users experience adverse health effects. Results of this study may help policy-makers develop standards for different types of tobacco.
Detailed description
PRIMARY OBJECTIVE: Examine the short-term impacts of vaping on pulmonary and respiratory outcomes. OUTLINE: Current e-cigarette users will vape their own e-cigarette device ad libitum for 30 minutes; non-users will watch a neutral video for 30 minutes. Before and after the 30 minute vaping \[video\] session, participants will undergo the following assessments: computer-based spirometry testing, nitric oxide breath testing, airwave oscillometry, and an assessment of endothelial function. Participants will also undergo collection of blood.
Interventions
PROCEDUREBiospecimen Collection
Undergo collection of blood
PROCEDURENitric Oxide Breath Test
Undergo nitric oxide breath testing
PROCEDUREOscillometry
Undergo airwave oscillometry
PROCEDURESpirometry
Undergo spirometry
OTHERSurvey Administration
Complete survey
PROCEDUREEndothelial function
Endothelial function will be assessed with the EndoPAT device, which measures changes in pressure from sensors placed on the fingertip
Sponsors
Ohio State University Comprehensive Cancer Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Years to 25 Years
Healthy volunteers
Yes
Inclusion criteria
* 75 e-cig users and 75 never-users * No self-reported diagnosis of lung disease (e.g., coronavirus disease-2019 \[COVID-19\], pneumonia, cystic fibrosis) * No history of cardiac event or distress * Not currently breastfeeding, pregnant, or planning to become pregnant (e-cig users only; will be confirmed via pregnancy test)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Airway inflammation as assessed by exhaled nitric oxide | Procedure will last approximately 3 minutes; the procedure will occur twice during the laboratory session (separated by approximately 60 minutes) | Exhaled nitric oxide will be measured in parts per billion (ppb) |
| Airway reactivity as assessed by airwave oscillometry | Procedure will last approximately 3 minutes; the procedure will occur twice during the laboratory session (separated by approximately 60 minutes) | Airway reactivity will be measured via Tremoflo, which is a well validated measurement of airway reactivity and provides curves of Resistance (R) and Reactance (X) |
| Respiratory functioning as assessed by a mobile Spirometry device | Procedure will last approximately 3 minutes; the procedure will occur twice during the laboratory session (separated by approximately 60 minutes) | Spirometry will collect daily data from participants on the relationship between their forced expiratory volume and forced vital capacity (measured as FEV1/FVC). |
| Endothelial function | Procedure will last approximately 20 minutes; the procedure will occur twice during the laboratory session (separated by approximately 90 minutes) | Endothelial function will be assessed with the EndoPAT device (unit of measurement = LnRHI). |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORMegan E Roberts, PhD
Ohio State University Comprehensive Cancer Center
Outcome results
None listed