BPD - Bronchopulmonary Dysplasia
Conditions
Brief summary
Assess the impact of steroid, diuretic, and fluid practices on BPD outcomes in extreme premature infants in the Banner - University Medical Center Phoenix (BUMCP) neonatal intensive care unit (NICU).
Detailed description
The investigators propose performing a retrospective analysis of the current respiratory management methods to potentially find a correlation between the number of steroid doses administered, the timing of initiation of steroid therapy and the effect on premature infants at risk for developing BPD. The investigators are also going to explore the number and timing of diuretic medications and average fluid intake.
Interventions
OTHERNo interventions or procedures
This is a retrospective observational study and data will be collected from the subject's existing medical record. No interventions or procedures will be required for this study.
Sponsors
Banner Health
Phoenix Children's Hospital
Pediatrix
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Infants born at \<30 weeks and/or \<1500g * Admitted to BUMCP between January 1, 2019 and December 31, 2020
Exclusion criteria
* Infants that do not survive to 36 weeks CGA, when the determination of BPD is made * Infants that are transferred to another hospital prior to 36 weeks CGA * Out born infants * Infants with life threatening congenital anomalies * Investigator discretion as to other factors which might impact the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To assess the impact of steroid practices on BPD outcomes in these infants | 30 days | \- The incidence of BPD stratified into three stages based on the type of support required at 36 weeks CGA |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To determine if steroid use has an impact on infant growth | 30 days | \- Collect growth and calculate the z-score at five intervals |
| To determine if steroid use has an impact on NICU length of stay (LOS) | 30 days | \- NICU LOS in days |
Other
| Measure | Time frame | Description |
|---|---|---|
| To determine if the average fluid intake in the first week of life influences the severity of BPD | 1-6 days | \- Fluid average from DOL 1-6 |
| To determine if diuretic administration influences the severity of BPD | 1-6 days | \- If applicable, the DOL of first furosemide and/or chlorothiazide doses |
Countries
United States
Outcome results
None listed