System; Lupus Erythematosus
Conditions
Brief summary
Systemic lupus erythematosus is a chronic and multisystemic autoimmune disorder which predominantly affecting women. The most common cause of death in lupus patients affected by disease for more than 5 years is cardiovascular disease due to presence of some factors as oxidative stress, pro-inflammatory cytokines , dyslipidemia, diabetes, and hypertension.
Detailed description
laser acupuncture (active or sham) for one month (3 days/week ) on acupoint number 14 of GV meridian, acupoint number 4 and 11 of large intestine, acupoint number 34 of gall bladder meridian, acupoint number 3 of liver meridian, acupoint number 4, 12, and 9 of conception vessel meridian, acupoint number 40, 36, and 25 of stomach meridian, acupoint number 6 of spleen meridian, and acupoint number 5 of triple energizer meridian (laser will be applied for 1 min on every acupiont) in lupus females
Interventions
DEVICElaser application on acupoints
laser acupuncture
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 47 Years
Healthy volunteers
No
Inclusion criteria
* lupus females * 60 patients
Exclusion criteria
* pregnancy * cardiovascular diseases * respiratory diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Malondialdehyde | It was measured after 4 weeks | anti-oxidative stress factor |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| diastole | It was measured after 4 weeks | blood pressure |
| blood glucose | It was be measured after 4 weeks | fasting |
| erythrocyte sedimentation rate (1 hour) | It was measured after 4 weeks | inflammatory marker |
| erythrocyte sedimentation rate (2 hour) | It was measured after 4 weeks | inflammatory marker |
| systole | It was measured after 4 weeks | blood pressure |
| adenosine triphosphate | It was measured after 4 weeks | energy production marker |
| Nitrate | It was measured after 4 weeks | oxidative stress factor |
| Glutathione | It was measured after 4 weeks | antioxidant marker |
| c reactive protein | It was measured after 4 weeks | inflammatory marker |
Countries
Egypt
Outcome results
None listed