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Role of Anterior Segment Optical Coherence Tomography in Infectious Keratitis

Role of Anterior Segment Optical Coherence Tomography in Staging and Evaluation of Treatment Response in Infectious Keratitis

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04969640
Enrollment
23
Registered
2021-07-21
Start date
2021-07-01
Completion date
2021-12-31
Last updated
2023-03-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infective Keratitis

Brief summary

To evaluate the role of anterior segment optical coherence tomography in follow up of infectious keratitis and assessment of response to treatment.

Detailed description

50 patients with proven infectious keratitis clinically will be included in the study. The following will be performed for all patients in initial visit and follow up: * Slit lamp examination and photography. * Visual acuity assessment. * Anterior segment optical coherence tomography. 1. The central corneal thickness (CCT) (extracted from pachymetry map), 2. Minimal corneal thickness (MCT) (extracted from pachymetry map) 3. Corneal thickness at the site of the lesion (CTL) (extracted from pachymetry map or the sum of STL+ CETL) 4. Stromal thickness at the center of the lesion (STL) stromal lesion (extracted from stromal map) 5. Corneal epithelial thickness over the stromal lesion (CETL) at the center of the lesion (extracted from epithelial map)

Interventions

OTHEROptical coherence tomography

Anterior segment optical coherence tomography examination of corneas with infective keratitis

Sponsors

Minia University
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* Any case with infectious keratitis (any age) either received medical treatment or not, attending to our department will be included in the study.

Exclusion criteria

* Cases with healed infectious keratitis. * Cases presented from the start with severe corneal affection and melting.

Design outcomes

Primary

MeasureTime frameDescription
criteria of lesion on optical coherence tomography1 monthLocaliztion, depth of infiltration area in microns
width of lesion on optical coherence tomography1 monthwidth of infiltration in microns

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026