Postoperative Delirium
Conditions
Brief summary
The purpose of this study is the efficiency of es-ketamine on postoperative delirium among old patients with elective lobectomy
Detailed description
This study aimed to investigate the effect of IV es-ketamine vs saline on the incidence of postoperative delirium. It was hypothesized that IV es-ketamine would reduce the incidence of in-hospital delirium during cardiac surgery lobectomy
Interventions
PROCEDURElobectomy
Intravenous es-ketamine 0.5mg/kg or saline during lobectomy
Sponsors
Zhongnan Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 60 years old; There is no limit on the gender, ASA (American Society of Anesthesiologists )Ⅰ-Ⅲ
Exclusion criteria
* Emergency surgery, severe hepatic and renal dysfunction, shock or coma, psychiatric disease or central nervous system disorder or a history of long-term use of psychiatric medications, cognitive dysfunction, severe arrhythmia or bradycardia, ketamine allergy,drug abuse history and used other sedatives for nearly a week
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative Delirium | 7 days after operation | Confusion Assessment Method (CAM) or CAM-ICU for patients |
| Postoperative Cognitive Assessment | 7 days after operation | Montreal Cognitive Assessment |
Outcome results
None listed