Anterior Cruciate Ligament Injuries, Cartilage Degeneration
Conditions
Keywords
sports biomechanics, joint loading, anterior cruciate ligament reconstruction, cartilage degeneration, functional MRI
Brief summary
Explore The Mechanism for the Effects of Joint Biomechanical Properties on Medial Cartilage of Tibiofemoral Joint Degeneration
Detailed description
Cartilage degeneration in the medial tibiofemoral joint is common after anterior cruciate ligament reconstruction (ACLR), which may develop into knee osteoarthritis (disability rate 21.3%). Alterations in joint biomechanical properties play an important role in cartilage degeneration after ACLR. However, the mechanism remains unclear. Our research studied the joint kinematics and kinetics properties after ACLR and found significant changes in biomechanics in the ACLR knees. Therefore, this study will combine longitude biochemical changes in the cartilage to explore how the alterations in biomechanics would influence biochemical changes in the joint cartilage. This study will explore the joint biomechanical properties during functional activities by motion analysis, the effects of biomechanical properties on cartilage stress distribution by finite element analysis, the long-term biochemical changes in the joint cartilage by functional MRI. This study will establish prediction models for cartilage biomechanical changes in the mid-term based on joint biomechanical properties in the early stage after ACLR, and cartilage biomechanical changes in the long-term based on joint biomechanical properties in the mid-term after ACLR. The study aims to clarify the mechanism of cartilage degeneration after ACLR and search biomechanical risk factors, in order to provide methods for clinical prevention of cartilage degeneration after ACLR.
Interventions
DIAGNOSTIC_TESTgait testing, functional MRI
diagnostic tests including the gait testing and functional MRI
Sponsors
Peking University Third Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
Unilateral ACL rupture of the knee
Exclusion criteria
concomitant with other ligament injury or rupture, with history of surgery or musculoskeletal system injury of the contralateral knee, and the time from injury to operation more than 8 weeks
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| knee T1 rho value | On the day of enrollment. | knee T1 rho value by functional MRI |
| knee T2 value | On the day of enrollment. | knee T1 rho value by functional MRI |
| knee extension angles | On the day of enrollment. | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping |
| knee moments | On the day of enrollment. | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping |
| ground reaction force | On the day of enrollment. | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping |
| knee rotation angles | On the day of enrollment. | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping |
Contacts
Primary ContactShuang Ren
Outcome results
None listed