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Refeeding Like Syndrome in Acute Disease

Dose-response Relation Between the Development of a Refeeding-like Syndrome and Sodium Balance in Patients Undergoing Acute Abdominal Surgery

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04966780
Acronym
RLS
Enrollment
48
Registered
2021-07-19
Start date
2018-04-01
Completion date
2021-06-01
Last updated
2021-07-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Abdomen, Refeeding Syndrome

Keywords

refeeding syndrome, acute abdominal disease

Brief summary

The refeeding syndrome has been reported without any evidence of prolopnged semistarvation, thus being different from the traditional disease. The investigators wanted to investigate, if sodium infusions could be part of the explanation.

Detailed description

Background: Refeeding syndrome is conventionally connected to start of feeding after prolonged periods of semi-starvation and adaption. However, it is also described in acutely ill patients and in ICU patients without a history of adaption, but sometimes only defined as a drop in p-phosphate without clinical manifestations. The investigators hypothesize, that a positive sodium balance could induce the refeeding-like syndrome (RLS). Method: Consecutive patients for acute, abdominal surgery were included and observed until discharge or up to seven days postoperatively with daily sodium and phosphate balance measurements.

Interventions

Acute surgery for acute abdominal disease

Sponsors

University of Copenhagen
CollaboratorOTHER
Jens Rikardt Andersen
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* age \> 18 yr * ready for acute surgery * able to understand and cooperate.

Exclusion criteria

* pregnancy or breastfeeding * renal insufficiency (p-creatinine\>400 micr mol/l) * re-operations * expected hospital stay \< 24 hours.

Design outcomes

Primary

MeasureTime frameDescription
sodium balance7 dayscorrelation between sodium balance and occurrence of the refeeding syndrome

Secondary

MeasureTime frameDescription
plasma phosphate7 dayscorrelation between sodium balance and change in plasma phosphate
urinary excretion of phosphate7 dayscorreletion between sodium balance and urinary excretion of phosphate
phosphate balance7 dayscorrelation between decline in plasma phosphate and urinary excretion of phosphate

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026