Microflora and Metabolomics of Crohn's Disease Patients

A Study Focused on the Microflora and Metabolomics of Crohn's Disease Patients

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04965584

Enrollment

Registered

2021-07-16

Start date

2021-08-01

Completion date

2022-07-31

Last updated

2021-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Crohn Disease

Keywords

Crohn's disease, microbiota, metabonomics

Brief summary

The purpose of this study is to explore the microflora characteristics of different ecological loci and multiple metabolic pathways in Crohn's disease patients with different disease course states.

Detailed description

This study aims to investigate the characteristics of microflora in the oral and tongue base, small intestinal stomy and lower respiratory tract, as well as the characteristics of multiple metabolic pathways such as bile acid metabolism and amino acid metabolism in Crohn's disease patients with different course states.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

1. individuals who were clear and signed the informed consent. 2. Male and female.

Exclusion criteria

1. Any one who can not provide accurate information. 2. Any one who denies the study.

Design outcomes

Primary

Measure	Time frame	Description
Oral microbiota structure and function difference between active stage of Crohn's disease, remission of Crohn's disease and healthy controls	3 months	The results were based on the 16S rRNA sequencing
Small intestinal microbiota structure and function difference between active stage of Crohn's disease, remission of Crohn's disease and healthy controls	3 months	The results were based on the 16S rRNA sequencing
Sputum microbiota structure and function difference between active stage of Crohn's disease, remission of Crohn's disease and healthy controls	3 months	The results were based on the 16S rRNA sequencing

Secondary

Measure	Time frame	Description
Metabolic difference of blood samples between active stage of Crohn's disease, remission of Crohn's disease and healthy controls	3 months	The metabolites of the blood samples by LC-MS will be detected

Countries

China

Contacts

Primary ContactKai Xia, MM

987239945@qq.com13588251107

Backup ContactRenyuan Gao, MD

renyuangao@126.com15601675695

Outcome results