Cannabis Use Disorder, Mild, Cannabis Use Disorder, Moderate, Cannabis Use Disorder, Severe
Conditions
Brief summary
Adults (ages 18+) who would like to reduce their cannabis use (N=224) will be enrolled in an 8-week treatment program. All participants will receive counseling (1 goals session with a therapist followed by 7 weekly computerized cognitive-behavioral therapy sessions). Detailed cannabis assessments (biological and self-report) will be conducted throughout treatment and at 1-, 2-, and 3-months post-treatment completion. Daily electronic diaries will be administered via text message to record detailed logs of cannabis use quantity and frequency. Salivary samples will be collected (and video observed) daily throughout treatment to analyze for progesterone.
Interventions
BEHAVIORALCognitive Behavioral Therapy (CBT4CBT)
Participants will receive one therapist-led motivational interviewing/goal setting session followed by 7 sessions of computerized CBT4CBT.
Sponsors
National Institute on Drug Abuse (NIDA)
Medical University of South Carolina
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Willingness to participate in a research study (otherwise, will be referred to appropriate clinical services if seeking clinical care). 2. Meet current (within last 30 days) DSM-5 criteria for cannabis use disorder. 3. Submit a positive urine cannabinoid test during screening. 4. Interested in treatment for cannabis use disorder.
Exclusion criteria
1. Significant or acutely unstable medical or psychiatric problems (i.e., psychosis, mania) that would contraindicate research procedures, interfere with safety, compromise data integrity, or preclude consistent study participation. 2. The presence of any substance use disorder requiring a higher level of care. 3. Significant risk of homicide or suicide. 4. Pregnant, trying to become pregnant, or breastfeeding.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of participants in remission | Week 4 | Remission is classified as the absence of DSM-5 cannabis use disorder symptoms (except cravings) as measured by semi-structured diagnostic interview. |
| Reduction in cannabis use days | 8 weeks of treatment | Number of cannabis use days assessed via daily diaries during treatment |
| Reduction in cannabis use episodes | 8 weeks of treatment | Number of cannabis use episodes assessed via daily diaries during treatment |
Countries
United States
Outcome results
None listed