Irreversible Pulpitis
Conditions
Brief summary
The aim of this study is to clinically compare post-operative pain levels after administration of preoperative single dose of sodium ibuprofen versus placebo for patient with symptomatic irreversible pulpitis related to mandibular molar teeth.
Detailed description
Oral pharmacologic agents have been the primary option, and the use of drugs has increased exponentially. Many pharmacological agents have been used to manage endodontic pain, including Non-steroidal Anti-inflammatory Drugs (NSAIDs),.administration of NSAIDs before root canal treatment will reduce inflammatory process before it begins. NSAIDs are widely used to control post endodontic pain They act by blocking the activity of cyclooxygenase (COX 1 and 2) enzyme. In human dental pulps with irreversible pulpitis, a higher level of expression of COX 2.In cases of irreversible pulpitis NSAIDS can be administered preoperatively since they reduce the level of prostaglandinE2(PGE2) which is responsible for sensitization of nociceptors. Ibuprofen is one of the most commonly used NSAIDs and a potent inhibitor of prostaglandin (PG) synthesis that can manage various pain types and has anti-inflammatory activity. Enhancements in ibuprofen acid's pharmacokinetics have led to the development of ibuprofen salts with a faster dissolution rate and onset of action. These ibuprofen salts.Fast acting ibuprofen like Sodium ibuprofen delivers maximum plasma drug concentrations at about 30-40 min, compared with around 90-120 min for standard ibuprofen acid formulations
Interventions
DRUGnurofen
tablet
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Masking description
drug will be put in sealed envelop and assistant supervisor will generate random sequence
Intervention model description
patient with symptomatic irriversible pulpitis
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients above 18 years old and below 66. * Male or female * Patients seeking root canal treatment * Mandibular posterior molarteeth with Symptomatic irreversible pulpitis . * Spontaneous pain * Systematically healthy patient(ASA I,II)
Exclusion criteria
* Medically compromised patients having significant systemic disorders. (ASA III or IV) * History of intolerance to NSAIDS. * Patients with two or more adjacent teeth requiring endodontic treatment. * External root resorption * Internal root resorption * Vertical root fracture * Periapical lesion * Pregnancy * Use of ibuprofen in the last 12 hour * Bleeding disorder * Long term corticosteroid use * Mobility Grade II or III. * Pocket depth more than 5mm. * Previous root canal therapy. * Non-restorability * Temporomandibular joint (TMJ) problems, bruxism, clenching or traumatic occlusion. * Inability to perceive the given instructions.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postoperative pain | Post-operative pain will be assessed immediately after treatment ,at 6 hours, at 12 hours, at 24 hours and 48 hours | pain will be measured by visual analogue scale(VAS). Postoperative pain levels were documented by the patients immediately after obturation, 6, 12, 24 and 48 hours post-treatment. The VAS consists a 10-cm line anchored by 2 extremes, ''no pain'' and ''pain as bad as it could be.'' Patients were asked to make a mark on the line that represents their level of perceived pain. Readings were transformed into categories; no pain (range of 0-4mm), mild pain (range of 5-44mm), moderate pain (range of 45-74mm) and severe pain (range of 75-100mm) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| need for rescue medication | Amount of analgesics taken by the patient after root canal treatment, up to 48 hours postoperatively | Amount of analgesics taken by the patient after root canal treatment |
Countries
Egypt
Outcome results
None listed