Periodontal Inflammation, Periodontitis
Conditions
Brief summary
For proving the potential of tropical medicaments on clinical parameters of periodontitis, a comprehensive assessment is required between therapeutic medicaments. The main aim of the study was to clinically evaluate and compare the efficacy of indocyanine green mediated photodynamic therapy (PDT) and aleo vera (AV) extract when used as an adjunct therapy to scaling and root planning (SRP) for treatment of chronic periodontitis. One hundred and fifty patients included in this study were randomly distributed in three treatment groups Group I (SRP), Group II (SRP+PDT) and Group III (SRP+AV). Four clinical parameters plaque index (PI), bleeding on probing (BoP), periodontal (PD) pocket depth and clinical attachment level (CAL) were evaluated at three time points baseline, 3rd and 6th month respectively. Additionally the amount of three inflammatory cytokines IL-6, IL-8 and TNF- α in gingival crevicular fluid (GCF) was identified using enzyme linked immune-sorbent assay (ELISA) technique.
Interventions
COMBINATION_PRODUCTPlant extract
Natural plant extract
Sponsors
Salah Abdalkreem Almohana
Abdulmohsen Khalid Alanazi
Abdulelah Khalid Alanazi
Alhanouf Abdulkarem Almohana
Riyadh Elm University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
30 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* age of ≥ 30 years; * ≥ 20 natural teeth; and * chronic-periodontitis (≥ 3 mm of CAL and PD pocket depth respectively on at least 30% of dental sites).
Exclusion criteria
* chronic systemic diseases; * PD therapy during last 6 months; * habitual use of chewable and non-chewable tobacco (smoking); * alcohol consumers; or * use of particular medications during last three months (steroidal and non-steroidal drugs/ anti-biotic/ anti-depressants)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinically Evaluating the Effects of Topical Indocyanine-green Mediated Photosensitizer VS Aloe vera Gel: Adjunct therapy to Scaling and Root Planing in Patients with Chronic Periodontitis | 9 months | Adjunct treatment regimens PDT and AV extract significantly helped in plummeting inflammation of PD tissue |
| IL-6 concentration in pg/ml | 6 months | Identify the concentration of IL-6 in the gingival crevicular fluid |
| IL-8 concentration in pg/ml | 6 months | Identify the concentration of IL-8 in the gingival crevicular fluid |
| TNF-α levels in pg/ml | 6 months | Identify the concentration of TNF-α in the gingival crevicular fluid |
| Periodontal pocket depth in mm | 6 months | Periodontal pocket depth |
| Clinical attachment loss in mm | 6 months | Periodontal attachment loss |
Countries
Pakistan, Saudi Arabia
Outcome results
None listed