Pulmonary Disease, Chronic Obstructive
Conditions
Brief summary
We aimed to collect clinical and radiological data of patients with stable COPD in plateau and plain, and compare the clinical phenotypic characteristics and imaging features of COPD patients in these two areas.
Detailed description
The purpose of this study was to investigate the clinical phenotypic characteristics and imaging features of patients with stable chronic obstructive pulmonary disease (COPD) in plateau and plain. We conducted a cross-sectional study, collecting clinical data of stable patients in plateau and plain, and comparing the clinical phenotypic characteristics and imaging features of COPD patients in these two areas.
Interventions
OTHERNo intervention
No intervention
Sponsors
Tibet Autonomous Region People's Hospital
Peking University Third Hospital
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* meeting the diagnosis of COPD according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines and had definite airflow limitation with a post-bronchodilator forced expiratory volume in 1 second (FEV1) / forced vital capacity (FVC)\<0.7.
Exclusion criteria
* age \<40 years; * subjects with airway diseases other than COPD; * acute exacerbation of COPD in the past 3 months; * active tuberculosis; * cardiovascular or cerebrovascular events in the past 3 months; * cognitive dysfunction such as vascular dementia or Alzheimer's disease; * refusal to participate in this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Exacerbation | Data were obtained during the interview. | Frequency of exacerbations in the past year |
| Spirometry testing | Data were obtained during the interview. | FEV1 %predicted, FVC %predicted, ratio of FEV1/FVC |
| Emphysema | Within 3 months of the interview. | The percentage of the LAA divided by total lung volumes (LAA%) was used as an index of the severity of emphysema in quantitative CT examination. |
| Assessment of respiratory symptoms | Data were obtained during the interview. | COPD Assessment Test |
| Airway remodeling -1 | Within 3 months of the interview. | Bronchial wall thickness (WT, mm) was used as one of the measurements for assessment of airway remodeling in quantitative CT examination. |
| Airway remodeling -2 | Within 3 months of the interview. | Luminal area (LA, mm2) was used as one of the measurements for assessment of airway remodeling in quantitative CT examination. |
| Airway remodeling -3 | Within 3 months of the interview. | Bronchial wall area (WA, mm2) was used as one of the measurements for assessment of airway remodeling in quantitative CT examination. |
Countries
China
Outcome results
None listed