Simplified Assessment of Left Ventricular Systolic Function in Septic Shock Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04963686

Acronym

MAPSE

Enrollment

Registered

2021-07-15

Start date

2021-09-20

Completion date

2021-12-20

Last updated

2026-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Left Ventricular Systolic Dysfunction, Septic Shock

Keywords

Left ventricular systolic function, global longitudinal strain, Septic Shock

Brief summary

The assessment of left ventricular systolic function is based on the measurement of left ventricular ejection function (LVEF) by the Simpson biplane method. More recently, left ventricular global longitudinal strain (GLS) has been developed to detect abnormalities of cardiac contractility in patients with preserved myocardial contractility. However, both tools are not always easy to collect in practice. This is why other ultrasound parameters have been proposed in the literature as a substitute for LVEF and GLS such as the Doppler tissue imaging (DTI)-derived mitral annular systolic peak S-wave velocity (S'), the mitral annular plane systolic excursion (MAPSE) and the longitudinal wall fractional shortening index (LWFS). The purpose of this project is to propose an algorithm using simple parameters (S' wave, lateral MAPSE, septal MAPSE, mean MAPSE and LWFS) to predict LVEF and GLS in order to diagnose patients with impaired systolic function and preserved ejection.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients hospitalized in the Medical Intensive Care Department of the Amiens-Picardie University Hospital for the management of septic shock. * Septic shock is defined by sepsis with a need for vasopressor amines to maintain a mean arterial pressure higher than or equal to 65 mmHg, and associated with hyperlactatemia (higher than 2 mmol/L). * A transthoracic echocardiography should be performed within 72 hours of the diagnosis of septic shock.

Exclusion criteria

* Patient with cardiac arrhythmias, * patients with severe mitral or aortic valve disease, * patients with fused mitral Doppler flow, * patients with insufficient echogenicity to allow a correct assessment of left ventricular systolic function.

Design outcomes

Primary

Measure	Time frame	Description
Concordance between LVEF and echocardiographic algorithm	3 months	left ventricular ejection function = LVEF The echocardiographic parameters used are: lateral S' wave; septal, lateral and mean MAPSE; and LWFS.
Concordance between GLS and echocardiographic algorithm	3 months	left ventricular global longitudinal strain = GLS The echocardiographic parameters used are: lateral S' wave; septal, lateral and mean MAPSE; and LWFS.

Countries

France

Outcome results