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Potential of Deep Learning in Assessing Pneumoconiosis Depicted on Digital Chest Radiography

Investigate the Potential of Deep Learning in Assessing Pneumoconiosis Depicted on Digital Chest Radiographs and to Compare Its Performance With Certified Radiologists

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04963348
Enrollment
1881
Registered
2021-07-15
Start date
2015-01-01
Completion date
2019-12-31
Last updated
2021-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pneumoconiosis

Brief summary

Pneumoconiosis is relatively prevalent in low/middle-income countries, and it remains a challenging task to accurately and reliably diagnose pneumoconiosis. The investigators implemented a deep learning solution and clarified the potential of deep learning in pneumoconiosis diagnosis by comparing its performance with two certified radiologists. The deep learning demonstrated a unique potential in classifying pneumoconiosis.

Detailed description

The investigators retrospectively collected a dataset consisting of 1881 chest X-ray images in the form of digital radiography. These images were acquired in a screening setting on subjects who had a history of working in an environment that exposed them to harmful dust. Among these subjects, 923 were diagnosed with pneumoconiosis, and 958 were normal. To identify the subjects with pneumoconiosis, the investigators applied a classical deep convolutional neural network (CNN) called Inception-V3 to these image sets and validated the classification performance of the trained models using the area under the receiver operating characteristic curve (AUC).

Interventions

OTHERconvolutional neural networks (CNNs)

CNN architecture named U-Net architecture

Sponsors

Peking University Third Hospital
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* industrial workers with a history of exposure to dust and underwent DR screening of pneumoconiosis from 2015 to 2018

Exclusion criteria

* patients with poor image quality * patients with incomplete clinical data

Design outcomes

Primary

MeasureTime frameDescription
the diagnosis of pneumoconiosisup to 6 monthsThe diagnosis and staging of pneumoconiosis were made by an expert panel consisting of certified radiologists and occupational physicians. The diagnosis of pneumoconiosis was confirmed by medical history and previous medical records(chest X-rays and pulmonary function testing).

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026