Bone Marrow Edema, Fractures, Bone
Conditions
Keywords
Spectral CT, Multi-Energy CT, Dual-Energy CT, Bone Marrow Edema
Brief summary
Dual-Energy/Multi-Energy/Spectral-CT can visualize bone marrow edema associated with fractures, however, current scientific evidence is mostly derived from to retrospective analyses. Our prospective study systematically analyzes the diagnostic accuracy of the visualization of bone marrow edema by including patients who are scheduled for a CT scan to exclude or further characterize a fracture. After giving informed consent, the CT scan will be performed using a dose-neutral Dual-Energy-/Multi-Energy-/Spectral-CT acquisition technique. If the patient undergoes MRI of the same region within 7 days, this scan will be used as a gold-standard for bone marrow edema. This will allow the quantification of diagnostic accuracy.
Interventions
DIAGNOSTIC_TESTComputed Tomography of the skeleton using a Dual-Energy-/Multi-Energy-/Spectral acquisition mode
CT acquisition using a Dual-Energy / Multi-Energy / Spectral acquisition mode
DIAGNOSTIC_TESTComputed Tomography of the skeleton using a conventional single-energy / non-spectral acquisition mode
CT acquisition using a standard single energy / non-spectral acquisition mode
Sponsors
University Hospital Augsburg
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* clinical suspicion for a fracture AND * indication for CT confirmed by board-certified radiologist ('justified indication' according to German/European radiation protection law) AND * patient (is able to give informed consent and) has given informed consent.
Exclusion criteria
* cardiorespiratory instability (as judged by the referring physician) * age \< 18 years * known or suspected pregnancy * known bone metastases of a malignant disease * known rheumatic disease * metal implants in the region to be scanned * surgical intervention over the last 12 months in the region to be scanned * contraindications for MRI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic Accuracy of Dual-Energy/Multi-Energy/Spectral CT to detect bone marrow edema in comparison with MRI as the goldstandard. | MRI of the same region can be used for comparison if performed within 7 days | sensitivity, specificity and positive and negative likelihood ratios will be assessed |
Countries
Germany
Contacts
Primary ContactSchwarz, MD
Outcome results
None listed