Hemianopia
Conditions
Keywords
visual cortex injury, stroke, blindness, cortical damage
Brief summary
The current proposal is to generate "proof of concept" evidence that hemianopia can be successfully rehabilitated in humans when this multisensory rehabilitation paradigm is used.
Detailed description
The over-arching objective is to evaluate the functional recovery of vision in hemianopic patients engaged with a multisensory training paradigm. Unilaterally blind participants will participate in weekly training sessions in which they are exposed to high-density spatiotemporally congruent and consistent visual-auditory stimulation. The participants will be tested on a battery of visual tasks probing different levels of function in different environments in a longitudinal study to track recovery.
Interventions
DEVICEmultisensory rehabilitation paradigm
In initial ("training") sessions, subjects will be exposed (and respond) to spatiotemporally congruent pairs of visual-auditory stimuli presented within their blinded field, with occasional probes of unisensory visual stimuli on both sides of space. Once recovery of visual responsiveness in the contralesional field is observed, sessions will alternate between "training/testing" and "testing only" sessions in which performance on the visual battery will be re-assessed.
Sponsors
Wake Forest University Health Sciences
Neuroscience Clinical Trial and Innovation Center (NCTIC)
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Subjects will participate in weekly sessions (1.5-2 hours) for three months which contain baseline testing, training, and repeated testing of visual recovery
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* adults (\<85) of either sex * diagnosis of a stable homonymous hemianopia (\>6 months) with absence of hemineglect * lesion encompassing at least primary visual cortex but sparing parietal cortex * normal auditory and cognitive function * willingness to participate in the three month program * ability to perform the visual discriminations in their intact field
Exclusion criteria
* adults (\>85) * normal auditory and cognitive function * unwilling to participate in the three month program * inability to perform the visual discriminations in their intact field
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Points Detected at Multiple Locations | Month 3 | To assess recovery of function - number of detected visual points in both hemifields (discrete count variable, higher values are "better") - Visual fields are divided into "affected" areas of the field (detection \< 50% on initial testing) and "intact" areas of the field (detection \> 50% on initial testing), aggregate data are reported for each at the start and end of study |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORBenjamin Rowland, PhD
Wake Forest Health Sciences
Baseline characteristics
| Characteristic | — |
|---|---|
| Age, Continuous | 67.6 years STANDARD_DEVIATION 3.5 |
| Ethnicity (NIH/OMB) Hispanic or Latino | 1 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 4 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants |
| Race (NIH/OMB) Asian | 0 Participants |
| Race (NIH/OMB) Black or African American | 1 Participants |
| Race (NIH/OMB) More than one race | 0 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) White | 4 Participants |
| Sex: Female, Male Female | 1 Participants |
| Sex: Female, Male Male | 4 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | 0 / 5 |
| other Total, other adverse events | 0 / 5 |
| serious Total, serious adverse events | 0 / 5 |
Outcome results
None listed