Infertility, Female
Conditions
Keywords
infertility, IVF , ICSI, endometrium, compaction
Brief summary
To record the dynamic change of endometrial thickness (Day of embryo transfer Versus. Day of ovulation trigger administration in case of fresh cycles or end of estrogen phase in frozen cycles), and to investigate the impact of endometrial thickness change on pregnancy outcomes
Detailed description
Clinical pregnancy rate in IVF cycles depends on embryo quality and endometrial receptivity . It is challenging to assess endometrial receptivity. Measuring endometrial thickness by ultrasonography is a simple , noninvasive and accurate method to do so. Many studies have implicated endometrial thickness and pattern as prognostic parameters for successful outcomes in IVF-ET. Some studies have suggested a minimal thickness for a successful pregnancy to occur, while others have reported adverse effects of increased endometrial thickness above which pregnancy is unlikely to occur. Now there is a novel hypothesis that not only the initial endometrial thickness can affect implantation rate and clinical pregnancy rate ,but also the decrease in endometrial thickness in the time interval between the ovulation triggering and the embryo transfer or what is called endometrial compaction increases the implantation and clinical pregnancy rate
Interventions
DIAGNOSTIC_TESTtransvaginal ultrasound on the uterus
Transvaginal ultrasound measurement to record endometrial thickness 2 times in each cycle: In case of fresh cycles: 1)Day of ovulation triggering 2)Day of embryo transfer In case of frozen thawed cycles : 1)End of estrogen phase 2)Day of embryo transfer
Sponsors
Assiut University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* • Infertile women aged 18 years to 40 years undergoing IVF/ ICSI for any indication.
Exclusion criteria
* • History of recurrent pregnancy loss (≥ 2 spontaneous abortions) and/or history of recurrent (≥ 2) ICSI failure after embryo transfer. * Uterine malformations. * Uncorrected hydrosalpinx. * Intrauterine conditions affecting pregnancy outcomes such as ( intrauterine adhesions, fibroids, polyps). * Any previous hysteroscopic surgery eg. Metroplasty or hysteroscopic myomectomy or uterine surgeries involving the endometrium eg. myomectomy during which uterine cavity was opened. * History suggesting endometritis. * Use of hCG for endometrial preparation or luteal phase support. * Poor quality embryos( according to Istanbul consensus workshop on embryo assessment )
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ongoing pregnancy rate | 12 weeks after embryo transfer if hCG tested positive | rate of ongoing pregnancy in patients who have endometrial compaction |
Countries
Egypt
Contacts
Primary ContactAyman Askar, master
Outcome results
None listed