Ultrasonographic Evaluation of the Diaphragm During NHF Versus NIV Use in Respiratory Failure

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04962568

Acronym

SENNI

Enrollment

Registered

2021-07-15

Start date

2021-07-07

Completion date

2022-09-05

Last updated

2022-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diaphragm Issues, Non-invasive Mechanical Ventilation, Respiratory Failure With Hypercapnia, Respiratory Failure With Hypoxia

Brief summary

This study will describe influence of NHF or NIV to different ultrasonographic parameters of the diaphragm. Therefor subjects will be randomized to the sequence NHF and than NIV or NIV and than NHF. In all subjects same parameters will be evaluated.

Interventions

DIAGNOSTIC_TESTDEx

diaphragm excursion during rest and diaphragmatic excursion during maximal inspiration in mm

DIAGNOSTIC_TESTDTEE

endexpiratory diaphragm thickness in mm

DIAGNOSTIC_TESTDTEI

endinspiratory diaphragm thickness in mm

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* acute or chronic respiratory failure, hyperemic or hypercapnic * age \> 18 yrs * written consent

Exclusion criteria

* critical disease (intubation, heart failure, lung edema,..) * no compliance * metabolic acidosis

Design outcomes

Primary

Measure	Time frame	Description
Changes in DTEE	10 minutes	Evaluation from baseline and between devices

Secondary

Measure	Time frame	Description
Changes in DTEI	10 minutes	Evaluation from baseline and between devices
Changes in Dex	10 minutes	Evaluation from baseline and between devices

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026