Carpal Tunnel Syndrome, Chronic Pain
Conditions
Brief summary
Carpal tunnel syndrome (CTS) is a common mononeuropathy due to entrapment of the median nerve in the carpal tunnel. a lot of modaleties are available for treatment of mild to moderate CTS.
Detailed description
Carpal tunnel syndrome (CTS) is a common mononeuropathy due to entrapment of the median nerve in the carpal tunnel. a lot of modaleties are available for treatment of mild to moderate CTS. In case of failed conservative oral therapey, local hydro-dessction of the median nerve can be done with saline alone. local anethetics, steroids, hyalase,and ozone have been utilized to augment the symptoms reliefe. Dexmeditomidine (DEX) has been studied as adjuvant for nerve block to aumnet the pain reliefe. Recently, it has been discovered that DEX can offer some antinflammatory effects when injected in the perineural area. Upon such discovery, the goal of this study has been built.
Interventions
DRUGDexmedetomidine
injection of Dexmedetomidine ( 10 microgram/kg) + 10 cc saline injection nearby median nerve as hydro-dissection
DRUGTriamcinolone
injection of triamcinolone ( 40 mg) + 10 cc saline injection nearby median nerve as hydro-dissection
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Intervention model description
Parallel Assignment Investigate if, and to what extent,carapl tunnel hydro-dissection using DEX or triamcinolone (TM) along with saline, under ultrasound guidance, can improve the clinical condition, change in nerve conduction parameters of patients with CTS and delay or avoid the surgical intervention.
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* adult patients * complaining of carpal tunnel syndrome of 3 month duration or more * diagnosed axonal neuropathy using electrodiagnosis , nerve conduction study
Exclusion criteria
* patient refusal * infection at the site of intervention * allergy to utilized drugs * diabetic * previous surgery in the site of injection * previous injection in the targeted site within the last year
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| pain visual analoge scale | 6 months | visual analog scale of pain value of (0 cm) no pain , and value of (10 cm) worst pain |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change of cross sectional area of the median nerve | 6 months | change of cross sectional area of the median nerve mm2 |
Countries
Egypt
Outcome results
None listed