Colorectal Polyposis
Conditions
Brief summary
Patients suspected of adenomatous polyposis were included. The criteria used were more than 10 polyps observed under colonoscopy, and pathological confirmation of adenoma. Clinical data and pedigree information were collected. The variants of 139 genes associated with different hereditary cancers and polyposis were screened by NGS, which was performed by Genetron Health on the HiSeqX-ten sequencing platform.
Interventions
GENETICgermline variants
Variants of 139 genes associated with different hereditary cancers and polyposis were screened by next-generation sequencing.
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
1. clinical diagnosis of adenomatous polyposis; 2. enough samples (provide at least 5ml of peripheral whole blood) for germline variant detection
Exclusion criteria
genetic diagnosis of polyposis syndrome
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| germline variant detection rate in the polyposis population | through study completion, an average of 3 years | germline variant detection rate in the polyposis population |
Countries
China
Contacts
Primary ContactYing Yuan, PhD
Backup ContactDong Xu, PhD
Outcome results
None listed