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Evaluating the Efficacy of Cranial Electrotherapy Stimulation in Mitigating Anxiety-induced Cognitive Deficits

Evaluating the Efficacy of Cranial Electrotherapy Stimulation in Mitigating Anxiety-induced Cognitive Deficits

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04961112
Enrollment
124
Registered
2021-07-14
Start date
2021-09-06
Completion date
2025-04-07
Last updated
2025-04-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anxiety, Cognitive Deficit

Keywords

Cranial electrotherapy stimulation, Executive functioning, Induced Anxiety, Cognition, Threat of shock, Heart rate variability

Brief summary

This study investigates the potential of cranial electrotherapy stimulation to mitigate anxiety induced cognitive deficits

Interventions

Participants will receive cranial electrotherapy stimulation stimulation on one of two separate visits (within-subjects).

Participants will receive sham stimulation on one of two separate visits (within-subjects).

Sponsors

Tufts University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)

Masking description

All study staff are blinded to active and sham brain stimulation devices until the completion of data collection.

Eligibility

Sex/Gender
ALL
Age
18 Years to 28 Years
Healthy volunteers
Yes

Inclusion criteria

* Between 18-28 years old

Exclusion criteria

* History of diagnosis with a neurological or psychiatric disorder.

Design outcomes

Primary

MeasureTime frameDescription
Task switching68 weeksSwitch cost (mean switch reaction time- mean stay reaction time)
Working memory (N-back)68 weeks2-back condition mean accuracy
Inhibition (Stroop)68 weeksStroop interference cost (mean incongruent reaction time- mean congruent reaction time)
Processing speed (Simple reaction time task)68 weeksMean reaction time

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026