Shear-wave Elastography Compared to Respiratory Function Testing

Comparison of Shear-wave Elastography to State-of-the-art Respiratory Function Testing to Measure the Range of Forces Generated by the Diaphragm Muscle

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04959526

Enrollment

Registered

2021-07-13

Start date

2021-07-28

Completion date

2026-12-01

Last updated

2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Complication, Respiratory Function Loss

Keywords

Elastography, Ultrasound

Brief summary

The purpose of this study is to evaluate the relationship between transdiaphragmatic pressure (Pdi) and diaphragm shear-wave elastography (SWE) during state-of-the-art respiratory muscle testing including volitional efforts (e.g., maximal inspiratory pressure, maximal expiratory pressure, Valsalva maneuver), as well as maximal phrenic nerve stimulation.

Interventions

DIAGNOSTIC_TESTShear-wave elastography

Ultrasound based imaging of diaphragm muscle activity

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

\- Adult male and female healthy volunteers.

Exclusion criteria

* Volunteers who are pregnant. * Volunteers with known pulmonary pathology (COPD, asthma requiring routine treatment).

Design outcomes

Primary

Measure	Time frame	Description
Shear wave speed	3 hours	Elastography of the diaphragm muscle across various behaviors and conditions

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORCarlos Matilla, MD, PhD

Mayo Clinic

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 17, 2026